Wen Shuai, An Ran, Li Zhi-Gang, Lai Zhao-Xiang, Li Dong-Li, Cao Jun-Xi, Chen Ruo-Hong, Zhang Wen-Ji, Li Qiu-Hua, Lai Xing-Fei, Sun Shi-Li, Sun Ling-Li
Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou, China.
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China.
Food Nutr Res. 2022 Jun 10;66. doi: 10.29219/fnr.v66.7652. eCollection 2022.
Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disease that easily induces hepatitis, cirrhosis, and even liver cancer. The long-term use of NAFLD therapeutic drugs produces toxicity and drug resistance. Therefore, it is necessary to develop high efficiency and low-toxicity active ingredients to alleviate NAFLD.
This study aimed to reveal the role and mechanism of a new functional food CMT in alleviating NAFLD.
In the ob/ob fatty liver mice models, the CMT extracts significantly inhibited the weight gain of the mice and reduced the accumulation of white fat. The anatomical and pathological results showed that CMT relieved fatty liver in mice and reduced excessive lipid deposition and inflammatory infiltration. Serological and liver biochemical indicators suggest that CMT reduced dyslipidemia and liver damage caused by fatty liver. CMT obviously activated the adenosine 5'-monophosphate-activated protein kinase (AMPK)/acetyl-coA carboxylase (ACC) and AMPK/fatty acid synthase (FAS) signaling pathways, promoted fat oxidation, and inhibited synthesis. Moreover, CMT regulated the expression of inflammatory factors to relieve hepatitis caused by NAFLD.
The study explained the role and mechanism of CMT in alleviating NAFLD and suggested that the active ingredients of CMT might be beneficial in NAFLD therapy.
非酒精性脂肪性肝病（NAFLD）是一种慢性代谢性疾病，易诱发肝炎、肝硬化甚至肝癌。长期使用NAFLD治疗药物会产生毒性和耐药性。因此，有必要开发高效低毒的活性成分来缓解NAFLD。
本研究旨在揭示新型功能性食品CMT在缓解NAFLD中的作用及机制。
在ob/ob脂肪肝小鼠模型中，CMT提取物显著抑制小鼠体重增加，减少白色脂肪堆积。解剖和病理结果显示，CMT可缓解小鼠脂肪肝，减少脂质过度沉积和炎症浸润。血清学和肝脏生化指标表明，CMT可减轻脂肪肝引起的血脂异常和肝损伤。CMT明显激活腺苷酸活化蛋白激酶（AMPK）/乙酰辅酶A羧化酶（ACC）和AMPK/脂肪酸合酶（FAS）信号通路，促进脂肪氧化，抑制脂肪合成。此外，CMT调节炎症因子表达以缓解NAFLD引起的肝炎。
本研究阐述了CMT在缓解NAFLD中的作用及机制，提示CMT的活性成分可能对NAFLD治疗有益。
