State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Front Immunol. 2022 Jun 9;13:906294. doi: 10.3389/fimmu.2022.906294. eCollection 2022.
Integrins are a large group of cell-surface proteins that are classified as transmembrane proteins. Integrins are classified into different types based on sequence variations, leading to structural and functional diversity. They are broadly distributed in animals and have a wide range of biological functions such as cell-to-cell communication, intracellular cytoskeleton organization, cellular signaling, immune responses, etc. Integrins are among the most abundant cell surface proteins in insects, exhibiting their indispensability in insect physiology. Because of their critical biological involvement in physiological processes, they appear to be a novel target for designing effective pest control strategies. In the current literature review, we first discuss the discovery and expression responses of integrins against various types of pathogens. Secondly, we examine the specific biological roles of integrins in controlling microbial pathogens, such as phagocytosis, encapsulation, nodulation, immune signaling, and so on. Finally, we describe the possible uses of integrins to control agricultural insect pests.
整合素是一大类细胞表面蛋白，被归类为跨膜蛋白。整合素根据序列变化分为不同类型，导致结构和功能的多样性。它们广泛分布于动物中，具有多种生物学功能，如细胞间通讯、细胞内细胞骨架组织、细胞信号转导、免疫反应等。整合素是昆虫中最丰富的细胞表面蛋白之一，在昆虫生理学中表现出不可或缺的作用。由于它们在生理过程中具有重要的生物学参与，因此它们似乎是设计有效害虫防治策略的新目标。在当前的文献综述中，我们首先讨论了整合素对各种类型病原体的发现和表达反应。其次，我们研究了整合素在控制微生物病原体方面的具体生物学作用，如吞噬作用、包被作用、结节形成、免疫信号转导等。最后，我们描述了整合素在控制农业害虫方面的可能用途。
