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埃塞俄比亚结核病与糖尿病的共病情况及相关危险因素：一项系统评价与荟萃分析

Co-occurrence of tuberculosis and diabetes mellitus, and associated risk factors, in Ethiopia: a systematic review and meta-analysis.

作者信息

Alemu Ayinalem, Bitew Zebenay Workneh, Diriba Getu, Gumi Balako

机构信息

Ethiopian Public Health Institute, Addis Ababa, Ethiopia.

Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.

出版信息

IJID Reg. 2021 Oct 20;1:82-91. doi: 10.1016/j.ijregi.2021.10.004. eCollection 2021 Dec.

DOI:10.1016/j.ijregi.2021.10.004
PMID:35757829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9216412/
Abstract

OBJECTIVE

The aim of our study was to estimate the pooled prevalence of tuberculosis (TB) and diabetes mellitus (DM) co-occurrences, and associated risk factors, in Ethiopia.

METHODS

In total, 392 articles were identified, and 14 were included in the analysis. The study's quality was assessed using the JBI tool. Data were analyzed using STATA version 16. The pooled prevalences of TB among DM patients and of DM among TB patients, with 95% CI, were estimated. In addition, the pooled OR values for each risk factor were estimated. The study's heterogeneity was assessed using forest plots and the heterogeneity test. Publication bias was assessed using funnel plots and Egger's regression test.

RESULTS

The pooled prevalence of TB among DM patients was 4.14% (95% CI 2.45-5.83%). The pooled prevalence of DM among TB patients was 12.77% (95% CI 6.91-18.62%). Type 1 DM patients had a higher TB risk (OR 2.70, 95% CI 1.41-3.99). Older age (OR 2.25, 95% CI 1.38-3.13) and family DM history (OR 3.65, 95% CI 1.89-5.41) were associated with DM co-occurrence among TB patients.

CONCLUSIONS

Higher prevalences of TB among DM patients and of DM among TB patients were noted in Ethiopia, when compared with the general population. Thus, active screening of DM patients for TB and vice versa is recommended.

摘要

目的

我们研究的目的是估计埃塞俄比亚结核病（TB）与糖尿病（DM）并发的合并患病率及相关危险因素。

方法

共识别出392篇文章，14篇纳入分析。使用JBI工具评估研究质量。采用STATA 16版分析数据。估计糖尿病患者中结核病的合并患病率以及结核病患者中糖尿病的合并患病率，并给出95%置信区间。此外，估计每个危险因素的合并比值比（OR）值。使用森林图和异质性检验评估研究的异质性。使用漏斗图和Egger回归检验评估发表偏倚。

结果

糖尿病患者中结核病的合并患病率为4.14%（95%置信区间2.45 - 5.83%）。结核病患者中糖尿病的合并患病率为12.77%（95%置信区间6.91 - 18.62%）。1型糖尿病患者患结核病的风险更高（OR 2.70，95%置信区间1.41 - 3.99）。年龄较大（OR 2.25，95%置信区间1.38 - 3.13）和家族糖尿病病史（OR 3.65，95%置信区间1.89 - 5.41）与结核病患者中糖尿病的并发有关。

结论

与普通人群相比，埃塞俄比亚糖尿病患者中结核病以及结核病患者中糖尿病的患病率更高。因此，建议对糖尿病患者进行结核病的主动筛查，反之亦然。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/a8da145608a1/gr10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/a8da145608a1/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/e89b7e6ef75a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/c91c54ef9782/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/27bbf9990a52/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/76cf4652627b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/1071c176c5ce/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/0133e5fa8fc0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/14151e29e759/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/be1abfad37a5/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/28e56ce47844/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7116/9216412/a8da145608a1/gr10.jpg

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