Wagner F
Reg Anaesth. 1987 Jan;10(1):16-23.
In a retrospective study clinical experience with epidural Bupivacaine 0.75% for laparoscopy is presented; the main interest of the study is focused on the relaxation of the abdominal wall musculature as expressed by compliance: volume of CO2-insufflation/pressure. Data of 55 patients were collected (= Group A) divided into 3 subgroups according to dosage: subgroup I = 15.0 ml = 112.5 mg (n = 12), II = 17.5 ml = 131.25 mg (n = 16), III = 20.0 ml = 150.0 mg (n = 27). These 55 patients are compared with two other groups of patients: group B = epidural anaesthesia with etidocaine 1.5% (n = 14) and group C = general anaesthesia with pancuronium as muscle relaxant 0.08 mg/kg (n = 7). Within group A the 3 subgroups do not show much difference except for one significant difference (p less than 0.05): between subgroup I and III concerning the upper limits of analgesia (1.5 segments: T 7 vs T 5/6), in the lowest dose-group the patients having the lowest weight (p less than 0.05). There was interdependence only with respect to two items: spread of analgesia (upper limit) depending on total dose (p less than 0.01) and on age (p less than 0.05), as well as dose/segment depending on age (p less than 0.01); despite statistical significance the correlation was rather weak.(ABSTRACT TRUNCATED AT 250 WORDS)
本文呈现了一项关于0.75%布比卡因硬膜外麻醉用于腹腔镜手术的回顾性临床研究;该研究的主要关注点在于通过顺应性(二氧化碳充气量/压力)所体现的腹壁肌肉松弛情况。收集了55例患者的数据(=A组),根据剂量分为3个亚组:亚组I = 15.0毫升 = 112.5毫克(n = 12),II = 17.5毫升 = 131.25毫克(n = 16),III = 20.0毫升 = 150.0毫克(n = 27)。将这55例患者与另外两组患者进行比较:B组 = 1.5%依替卡因硬膜外麻醉(n = 14),C组 = 以0.08毫克/千克泮库溴铵作为肌肉松弛剂的全身麻醉(n = 7)。在A组内,3个亚组除了一个显著差异(p < 0.05)外,差异不大:亚组I和III在镇痛上限方面(1.5个节段:T7与T5/6)存在显著差异,在最低剂量组中患者体重最低(p < 0.05)。仅在两个项目上存在相互依存关系:镇痛范围(上限)取决于总剂量(p < 0.01)和年龄(p < 0.05),以及剂量/节段取决于年龄(p < 0.01);尽管具有统计学意义,但相关性相当弱。(摘要截断于250字)