Shandong Sport University, Jinan, Shandong Province, China.
Medicine (Baltimore). 2022 Jun 24;101(25):e29248. doi: 10.1097/MD.0000000000029248.
Oncogenic microRNAs, a kind of stable epigenetic inhibitors, often deregulated in Mycosis fungoides (MF) which affect the skin and tend to transform and spread.
Previous studies investigating the de-expression of microRNA in MF patients skin biopsies identified that they were not only regulated by signaling pathway, but also regulated other signaling pathway. Furthermore, studies have elucidated the molecular mechanisms of the STAT signaling pathway that can promote a great diversity of miRNA expression via cytokine binding receptors, activating Janus kinase-3 and STAT proteins. But some non-STAT signaling pathway with mircoRNA de-expression in MF was incomplete.
Taken together, these studies demonstrate that microRNA may be used as the prognosis, progression and diagnose of MF, as they can not only control MF cell proliferation, but also induce MF cell apoptosis.
致癌 microRNAs 是一种稳定的表观遗传抑制剂，在蕈样肉芽肿（MF）中常失调，影响皮肤并倾向于转化和扩散。
先前研究调查了 MF 患者皮肤活检中 microRNA 的表达下调，发现它们不仅受信号通路调控，还受其他信号通路调控。此外，研究阐明了 STAT 信号通路的分子机制，该机制可以通过细胞因子结合受体、激活 Janus 激酶-3 和 STAT 蛋白来促进大量 miRNA 表达。但在 MF 中，一些非 STAT 信号通路的 microRNA 表达下调并不完全。
综上所述，这些研究表明，microRNA 可作为 MF 的预后、进展和诊断标志物，因为它们不仅可以控制 MF 细胞增殖，还可以诱导 MF 细胞凋亡。
