Balakrishnan Venkadesh, Ganguly Anirban, Rasappan Ramesh
School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Vithura, Thiruvananthapuram, Kerala 695551, India.
Org Lett. 2022 Jul 8;24(26):4804-4809. doi: 10.1021/acs.orglett.2c01862. Epub 2022 Jun 27.
The hydrogen borrowing strategy is an economical method for the α-functionalization of ketones. While this strategy is extremely advantageous, it does not lend itself to the synthesis of β,β-disubstituted ketones. This can be achieved, if the in situ generated metal hydride can be intercepted with a nucleophilic coupling partner. We present a multicomponent strategy for the coupling of alcohols, ketones, and boronic acids using only 1 mol % nickel catalyst and without the need for added ligands.
氢转移策略是一种用于酮α-官能化的经济方法。虽然该策略极具优势，但并不适用于β,β-二取代酮的合成。如果原位生成的金属氢化物能够被亲核偶联试剂捕获，那么这一目标就可以实现。我们提出了一种多组分策略，仅使用1 mol%的镍催化剂，无需添加配体，即可实现醇、酮和硼酸的偶联反应。
