Sakthivel Kokila, Gana R J, Shoji Toshitaka, Takenaga Naoko, Dohi Toshifumi, Singh Fateh V
Chemistry Division, School of Advanced Sciences, Vellore Institute of Technology (VIT), Chennai, Tamil Nadu, India.
Graduate School of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.
Front Chem. 2023 Sep 8;11:1217744. doi: 10.3389/fchem.2023.1217744. eCollection 2023.
To prepare complicated organic molecules, straightforward, sustainable, and clean methodologies are urgently required. Thus, researchers are attempting to develop imaginative approaches. Metal-catalyzed multicomponent reactions (MCRs) offer optimal molecular diversity, high atomic efficiency, and energy savings in a single reaction step. These versatile protocols are often used to synthesize numerous natural compounds, heterocyclic molecules, and medications. Thus far, the majority of metal-catalyzed MCRs under investigation are based on metal catalysts such as copper and palladium; however, current research is focused on developing novel, environmentally friendly catalytic systems. In this regard, this study demonstrates the effectiveness of metal catalysts in MCRs. The aim of this study is to provide an overview of metal catalysts for safe application in MCRs.
为了制备复杂的有机分子，迫切需要直接、可持续且清洁的方法。因此，研究人员正在尝试开发富有想象力的方法。金属催化的多组分反应（MCRs）在单个反应步骤中提供了最佳的分子多样性、高原子效率和能源节约。这些通用的反应方案常用于合成众多天然化合物、杂环分子和药物。到目前为止，大多数正在研究的金属催化MCRs是基于铜和钯等金属催化剂；然而，目前的研究重点是开发新型的、环境友好的催化体系。在这方面，本研究展示了金属催化剂在MCRs中的有效性。本研究的目的是概述金属催化剂在MCRs中的安全应用。
