Coelho J C, Senninger N, Runkel N, Herfarth C, Messmer K
Res Exp Med (Berl). 1987;187(1):19-24. doi: 10.1007/BF01854964.
The effect of the calcium-channel blocker nifedipine on the electromyographic activity of the small bowel and sphincter of Oddi was studied in conscious opossums. Electromyographic and arterial pressure recordings were started 7-10 days after implantation of seven pairs of electrodes along the small bowel and sphincter of Oddi. Continuous infusion of nifedipine caused a dose-dependent reduction of the frequency of spike bursts in the small bowel and sphincter of Oddi. Nifedipine at high doses abolished the migrating motor complex in the gastrointestinal tract. The frequency of slow waves was unchanged. This drug possibly inhibits the membrane influx of calcium into the smooth muscle cells of the gastrointestinal tract. We conclude that nifedipine causes an intense decrease in the motility of the small bowel and sphincter of Oddi.
在清醒的负鼠中研究了钙通道阻滞剂硝苯地平对小肠和Oddi括约肌肌电活动的影响。沿小肠和Oddi括约肌植入七对电极7 - 10天后开始进行肌电和动脉压记录。持续输注硝苯地平导致小肠和Oddi括约肌中棘波爆发频率呈剂量依赖性降低。高剂量硝苯地平消除了胃肠道中的移行性运动复合波。慢波频率未改变。这种药物可能抑制钙向胃肠道平滑肌细胞的膜内流。我们得出结论，硝苯地平可导致小肠和Oddi括约肌的运动性显著降低。
