Coelho J C, Moody F G
Dig Dis Sci. 1987 Jan;32(1):86-94. doi: 10.1007/BF01296692.
Applications of electromyographic and endoscopic manometric techniques in experimental and clinical studies have enhanced our knowledge of the normal physiology and motility disturbances of the sphincter of Oddi. The sphincter of Oddi has an active role in coordinating the time and rate of secretion of biliopancreatic juice into the duodenum. In the opossum, the sphincter of Oddi exhibits spontaneous contractions that migrate distally along the sphincter and expels its contents into the duodenum. Although the motor activity of the sphincter of Oddi is independent from that of the duodenum, there is a correlation between the frequency of bursts of spike potentials in the sphincter of Oddi and the migrating motor complex phases in the duodenum. Abnormal motility of the sphincter of Oddi has been reported during endoscopic manometric evaluation of patients with choledocholithiasis and sphincter of Oddi dyskinesia. Patients with common bile duct stones have an increase in the frequency of retrograde propagation of phasic waves. Elevation of basal pressure as well as an increase in the frequency and amplitude of sphincter of Oddi phasic waves and the common bile duct-duodenum gradient pressure may occur in patients with sphincter of Oddi dyskinesia. Endoscopic manometric studies of the sphincter of Oddi may become an important method to diagnose sphincter of Oddi dyskinesia.
肌电图和内镜测压技术在实验和临床研究中的应用，增进了我们对Oddi括约肌正常生理学及运动功能障碍的了解。Oddi括约肌在协调胆汁和胰液排入十二指肠的时间及速率方面发挥着积极作用。在负鼠中，Oddi括约肌会出现自发性收缩，这种收缩沿括约肌向远端迁移，并将其内容物排入十二指肠。尽管Oddi括约肌的运动活动独立于十二指肠，但Oddi括约肌中动作电位爆发的频率与十二指肠中移行性运动复合波的各期之间存在相关性。在对胆总管结石和Oddi括约肌运动障碍患者进行内镜测压评估时，已报告Oddi括约肌存在异常运动。胆总管结石患者的相波逆行传播频率增加。Oddi括约肌运动障碍患者可能会出现基础压力升高以及Oddi括约肌相波的频率和幅度增加，同时胆总管 - 十二指肠压力梯度也会增加。对Oddi括约肌进行内镜测压研究可能会成为诊断Oddi括约肌运动障碍的重要方法。
