Hultkvist U, Westergren G, Norrgren K, Lewan L
Res Exp Med (Berl). 1987;187(1):49-54. doi: 10.1007/BF01854968.
The distribution of systematically injected In-113m (t1/2 = 100 min) in organs of the rat was analyzed, and the use of the isotope for in vivo and in vitro gamma-radiation detection studies of blood plasma protein extravasation was demonstrated in skin, muscle, and tumor. In-113m was slowly excreted from rats. One to 6 h after injection the blood held 3% and 2%, respectively, of injected radioactivity/g tissue wet weight; skin and muscle held 0.1%-0.2%/g; liver, colon, and spleen held approximately 1%/g; lungs 1.5%-1.3%/g and kidneys 2.8%-3.3%/g. Scintillation camera technique revealed 40%-80% extraaccumulation of In-113m in a control extremity upon local administration of serotonin and 20%-40% in an extremity with a transplanted tumor, thus indicating a lower effect of serotonin in tumor microvascular circulation than in muscle and skin. In vitro detection of In-113m radiation by a well-counter in dissected tissues showed no effects of serotonin in the tumor and a four- to five-fold increase of radioactivity in muscle and skin, thus confirming blood protein extravasation upon serotonin treatment in these tissues. External analyses of In-113m in the vascular system using one miniaturized probe directed toward an area of interest showed that the method was too sensitive to movements of the animal, and second probe directed toward a control area is needed.
分析了系统性注射的铟 - 113m（半衰期 = 100分钟）在大鼠各器官中的分布情况，并证明了该同位素可用于皮肤、肌肉和肿瘤中血浆蛋白外渗的体内和体外γ辐射检测研究。铟 - 113m从大鼠体内排泄缓慢。注射后1至6小时，血液中放射性占注射放射性的比例分别为每克组织湿重的3%和2%；皮肤和肌肉中占0.1% - 0.2%/克；肝脏、结肠和脾脏中约占1%/克；肺中占1.5% - 1.3%/克，肾脏中占2.8% - 3.3%/克。闪烁相机技术显示，在局部给予血清素后，对照肢体中铟 - 113m的额外蓄积量为40% - 80%，而在移植肿瘤的肢体中为20% - 40%，这表明血清素在肿瘤微血管循环中的作用比在肌肉和皮肤中更低。通过井型计数器对解剖组织中铟 - 113m辐射的体外检测表明，血清素对肿瘤无影响，而肌肉和皮肤中的放射性增加了四到五倍，从而证实了血清素处理后这些组织中存在血液蛋白外渗。使用一个指向感兴趣区域的小型化探头对血管系统中的铟 - 113m进行外部分析表明，该方法对动物的运动过于敏感，需要第二个指向对照区域的探头。
