Hultkvist-Bengtsson U, Mårtensson L
Department of Zoophysiology, University of Lund, Sweden.
Thorax. 1990 Sep;45(9):688-93. doi: 10.1136/thx.45.9.688.
Accumulation of radioisotope labelled transferrin in the lungs of guinea pigs was determined with an external detection system. The method is based on the intravascular and extravascular distribution of indium-113m labelled transferrin compared with the intravascular distribution of technetium-99m labelled red blood cells. Guinea pigs were given iloprost, a prostacyclin analogue and potent pulmonary vasodilator, and noradrenaline, a pulmonary vasoconstrictor, in an attempt to increase and decrease respectively the blood volume in the lungs. Neither agent altered transferrin accumulation in the lung by comparison with a saline infusion. Iloprost infused before and after oleic acid infusion reduced macro-molecular leakage when compared with oleic acid alone. These data suggest that the double isotope method can distinguish between hydrostatic and injury induced pulmonary oedema.
使用外部检测系统测定放射性同位素标记的转铁蛋白在豚鼠肺部的蓄积情况。该方法基于铟 - 113m标记的转铁蛋白的血管内和血管外分布，并与锝 - 99m标记的红细胞的血管内分布进行比较。给豚鼠注射伊洛前列素（一种前列环素类似物和强效肺血管扩张剂）和去甲肾上腺素（一种肺血管收缩剂），试图分别增加和减少肺部的血容量。与输注生理盐水相比，这两种药物均未改变转铁蛋白在肺部的蓄积。与单独使用油酸相比，在油酸输注前后输注伊洛前列素可减少大分子渗漏。这些数据表明，双同位素方法可以区分静水压性肺水肿和损伤性肺水肿。
