Reyes-Villarreal Juan Carlos, Morales-Gutiérrez Joel Eduardo, López-Zamora Berenice, Reyes-Navarro Geraldine Vanessa, Ordoñez-González Irvin, Triana-González Salma, Peralta-Amaro Ana Lilia
Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Departamento de Medicina Interna. Ciudad de México, México.
Universidad Juárez Autónoma de Tabasco, Escuela de Medicina, División Académica de Ciencias de la Salud. Villahermosa, Tabasco, México.
Rev Med Inst Mex Seguro Soc. 2022 Mar 1;60(2):142-148.
The myocardial infarction-associated (MI) mortality is not only due cardiovascular complications, but intrahospital non-cardiovascular complications (IHnCVCs). The leuko-glycemic index (LGI) has been used as a prognostic marker for the development of cardiovascular complications in MI. We focused this study on identifying the cut-off point of LGI for the IHnCVCs development in patients with ST-segment elevation myocardial infarction (STEMI).
In this single-center and crosssectional design, we included patients with STEMI. The biochemical analysis included glucose and leucocytes; with them we calculated the LGI. Receiver operating characteristic curve, univariate and bivariate analysis, and multivariate analysis for IHnCVCs development were performed. A p < 0.05 was considered statistically significant.
We included 1294 patients, 79.8% were men and 20.2% women. The main comorbidities were hypertension, diabetes mellitus and dyslipidemia. Six hundred forty-four (49.8%) patients presented IHNCVCs. The LGI > 1200 (AUC 0.817) predict the IHNCVCs development in STEMI patients. The variables that increased the IHNCVCs development were LGI > 1200, creatinine > 0.91 mg/dL, diabetes mellitus and age > 65 years. Hospital acquired pneumonia and cardiovascular complications increase the risk of death among STEMI patients.
A LGI > 1200 increased, just over nine times, the risk of IHnCVC development in STEMI patients.
心肌梗死相关（MI）死亡率不仅归因于心血管并发症，还包括院内非心血管并发症（IHnCVCs）。白细胞血糖指数（LGI）已被用作MI中心血管并发症发生的预后标志物。我们将本研究重点放在确定ST段抬高型心肌梗死（STEMI）患者发生IHnCVCs时LGI的截断点。
在这项单中心横断面设计中，我们纳入了STEMI患者。生化分析包括血糖和白细胞；据此计算LGI。对IHnCVCs的发生进行了受试者工作特征曲线、单变量和双变量分析以及多变量分析。p<0.05被认为具有统计学意义。
我们纳入了1294例患者，其中男性占79.8%，女性占20.2%。主要合并症为高血压、糖尿病和血脂异常。644例（49.8%）患者出现IHNCVCs。LGI>1200（AUC 0.817）可预测STEMI患者发生IHNCVCs。增加IHnCVCs发生的变量为LGI>1200、肌酐>0.91mg/dL、糖尿病和年龄>65岁。医院获得性肺炎和心血管并发症增加了STEMI患者的死亡风险。
LGI>1200使STEMI患者发生IHnCVC的风险增加了九倍多。
