[Leuko-glycemic index as an in-hospital prognostic marker in patients with ST-segment elevation myocardial infarction].

INTRODUCTION

Blood glucose and white blood cell count on admission have demonstrated prognostic significance in patients with myocardial infarction; leuko-glycemic index, a recently proposed marker, still lacks enough knowledge about its value.

OBJECTIVES

To evaluate the leuko-glycemic index as a prognostic marker in patients with ST-segment elevation myocardial infarction.

METHODS

A retrospective study was carried out in 128 patients with ST-segment elevation myocardial infarction, who were admitted between January 2009 and October 2010 in the Intensive Care Unit of the Hospital Dr. Celestino Hernández Robau. Clinical and laboratory data were collected, including glucose and white blood cell count on admission, from which we calculated the leuko-glycemic index and we evaluated its prognostic value.

RESULTS

Patients who had a poor outcome such as death, major cardiac complications and failed-thrombolysis, showed higher values of leuko-glycemic index (P<.01), which was correlated with several variables such as Killip class, and heart rate on admission (P=.000). We obtained a cutoff point of 1.158, patients with higher values had 3 times higher probability of death and complications (odds ratio=3,0; IC 95%: 1,2-7,3; P=.005); so leuko-glycemic index was an independent predictor after multivariate analysis.

CONCLUSIONS

The leuko-glycemic index was associated with an increased occurrence of hospital complications, death and failed-thrombolysis; its pathological value was an independent predictor of in-hospital death and complications in the studied sample.