Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark.
Institue of Clinical Research, University of Southern Denmark, Odense, Denmark.
Scand J Clin Lab Invest. 2022 Jul;82(4):261-266. doi: 10.1080/00365513.2022.2064764. Epub 2022 Jun 27.
We have established and describe two measurement procedures to diagnose possible zinc (Zn) deficiency; albumin-corrected Zn concentration and available free Zn-binding capacity. Reference intervals for both biomarkers were established in healthy adults from the Danish population. The clinical usefulness of the measurement procedures was investigated in patients with cirrhosis and in patients given parenteral nutrition due to short bowel syndrome. The results of both methods indicate that there is a risk of overdiagnosing Zn deficiency based on low plasma Zn concentrations. Needless Zn supplementation may thus be avoided by using the albumin-corrected Zn concentration or available free Zn-binding capacity.
我们建立并描述了两种测量程序来诊断可能的锌（Zn）缺乏症; 白蛋白校正的 Zn 浓度和可用的游离 Zn 结合能力。在丹麦人群中的健康成年人中建立了这两个生物标志物的参考区间。在肝硬化患者和因短肠综合征而接受肠外营养的患者中研究了测量程序的临床实用性。这两种方法的结果均表明，基于低血浆 Zn 浓度，存在过度诊断 Zn 缺乏症的风险。因此，通过使用白蛋白校正的 Zn 浓度或可用的游离 Zn 结合能力，可以避免不必要的 Zn 补充。
