Yan L, Prentice A, Dibba B, Jarjou L M, Stirling D M, Fairweather-Tait S
Medical Research Council Dunn Nutrition Unit, Cambridge, The Gambia.
Br J Nutr. 1996 Dec;76(6):821-31. doi: 10.1079/bjn19960089.
The effect of long-term supplementation with CaCO3 on indices of Fe, Zn and Mg status was investigated in a randomized, double-blind intervention study of sixty lactating Gambian women. The supplement contained 1000 mg Ca and was consumed between meals 5 d/week, for 1 year starting 1.5 weeks postpartum. Compliance was 100%. Plasma ferritin concentration, plasma Zn concentration and urinary Mg output were measured before, during and after supplementation at 1.5, 13, 52 and 78 weeks postpartum. No significant differences in mineral status were observed at any time between women in the supplement and placebo groups. Analysis of the longitudinal data series showed that plasma ferritin and Mg excretion were characteristic of the individual (P < 0.001). Within individuals, ferritin concentration was higher at 1.5 weeks postpartum than later in lactation (P = 0.002). Plasma Zn concentration was lower at 1.5 weeks postpartum than at other times (P < 0.001), an effect which disappeared after albumin correction. Low plasma concentrations of ferritin and Zn indicated that the Gambian women were at high risk of Fe and Zn deficiency. Measurements of alpha 1-antichymotrypsin suggested that the results were not confounded by acute-phase responses. The results of the present study indicate that 1000 mg Ca as CaCO3 given between meals does not deleteriously affect plasma ferritin and Zn concentrations or urinary Mg excretion in women who are at risk of Fe and Zn deficiency.
在一项针对60名冈比亚哺乳期妇女的随机、双盲干预研究中，调查了长期补充碳酸钙对铁、锌和镁状态指标的影响。补充剂含有1000毫克钙，从产后1.5周开始，每周5天在两餐之间服用，持续1年。依从性为100%。在产后1.5、13、52和78周补充前后，分别测量血浆铁蛋白浓度、血浆锌浓度和尿镁排出量。补充剂组和安慰剂组女性在任何时候的矿物质状态均未观察到显著差异。对纵向数据系列的分析表明，血浆铁蛋白和镁排泄具有个体特征（P<0.001）。在个体内部，产后1.5周时铁蛋白浓度高于哺乳期后期（P = 0.002）。产后1.5周时血浆锌浓度低于其他时间（P<0.001），白蛋白校正后这种效应消失。血浆铁蛋白和锌浓度较低表明冈比亚妇女有缺铁和缺锌的高风险。α1-抗糜蛋白酶的测量结果表明，结果未受急性期反应的干扰。本研究结果表明，对于有缺铁和缺锌风险的女性，餐间服用1000毫克碳酸钙形式的钙不会对血浆铁蛋白和锌浓度或尿镁排泄产生有害影响。
