Günther K P, Tucker K, Kjaersgaard-Andersen P, Lützner J, Kretzer J P, Nelissen R, Lange T, Zagra L
UniversitätsCentrum für Orthopädie, Unfall- und Plastische Chirurgie, Universitätsklinikum Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
Orthopaedic Data Evaluation Panel (ODEP), Norwich, Großbritannien.
Orthopadie (Heidelb). 2022 Aug;51(8):638-645. doi: 10.1007/s00132-022-04276-z. Epub 2022 Jun 27.
Off-label use is frequently practiced in hip revision arthroplasty, as there may be indications for the application of implants for purposes outside the one the manufacturers intended (i.e. large bone and soft tissue defects, obesity). Patients may also benefit from selective application of mix & match in hip revision, when the exchange of one component only is necessary and the invasiveness of surgery can be reduced. Currently, there are no formal guidelines for these situations. Therefore, within a recent EFORT initiative, evidence- and consensus-based recommendations have been developed for the safe application of off-label use and mix & match in revision hip and knee arthroplasty.
非标签使用在髋关节翻修置换术中经常被采用，因为可能存在将植入物用于制造商预期之外目的的指征（例如大的骨和软组织缺损、肥胖）。当仅需更换一个组件且可降低手术创伤时，患者也可能从髋关节翻修术中选择性地应用混合搭配中获益。目前，针对这些情况尚无正式指南。因此，在欧洲骨与软组织修复学会（EFORT）近期的一项倡议中，已制定了基于证据和共识的建议，以安全应用髋关节和膝关节翻修术中的非标签使用及混合搭配。
