Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Division Operations, Cantonal Police Bern, Bern, Switzerland.
Immun Inflamm Dis. 2022 Jul;10(7):e640. doi: 10.1002/iid3.640.
To assess the risk for COVID-19 of police officers, we are studying the seroprevalence in a cohort. The baseline cross-sectional investigation was performed before a vaccination campaign in January/February 2021, and demonstrated a seroprevalence of 12.9%. Here, we demonstrate serosurveillance results after a vaccination campaign.
The cohort consists of 1022 study participants. The 3- and 6-month follow-up visits were performed in April/May and September 2021. Data on infection and vaccination rates were obtained via measuring antibodies to the nucleocapsid protein and spike protein and online questionnaires.
The mean age of the population was 41 (SD 8.8) years, 72% were male and 76% had no comorbidity. Seroconversion was identified in 1.05% of the study population at the 3-month visit and in 0.73% at the 6-month visit, resulting in an infection rate of 1.8% over a time period of 6 months. In comparison, the infection rate in the general population over the same time period was higher (3.18%, p = .018). At the 6-month visit, 77.8% of participants reported being vaccinated once and 70.5% twice; 81% had an anti-S antibody titer of >250 U/ml and 87.1% of ≥2 U/ml. No significant association between infection and job role within the department, working region, or years of experience in the job was found. Anti-spike antibody titers of vaccinated study participants showed a calculated decreasing trend 150-200 days after the second vaccine dose.
These data confirm the value of the vaccination campaign in an exposed group other than healthcare professionals.
为了评估警察感染 COVID-19 的风险，我们正在对一个队列进行血清流行率研究。基线横断面调查是在 2021 年 1 月/2 月疫苗接种活动之前进行的，结果显示血清阳性率为 12.9%。在这里，我们展示了疫苗接种活动后的血清监测结果。
该队列包括 1022 名研究参与者。在 2021 年 4 月/5 月和 9 月进行了 3 个月和 6 个月的随访。通过测量核衣壳蛋白和刺突蛋白抗体以及在线问卷调查来获取感染和疫苗接种率数据。
人群的平均年龄为 41（SD 8.8）岁，72%为男性，76%无合并症。在 3 个月访视时，研究人群中有 1.05%发生血清转化，在 6 个月访视时，有 0.73%发生血清转化，导致 6 个月内感染率为 1.8%。相比之下，同一时期普通人群的感染率更高（3.18%，p=0.018）。在 6 个月访视时，77.8%的参与者报告接种了一次，70.5%接种了两次；81%的人抗-S 抗体滴度>250 U/ml，87.1%的人抗-S 抗体滴度≥2 U/ml。在部门内部的工作角色、工作区域或工作经验年限方面，未发现感染与工作之间存在显著关联。接种疫苗的研究参与者的抗刺突抗体滴度在第二次疫苗接种后 150-200 天呈计算出的下降趋势。
这些数据证实了疫苗接种活动在医疗保健专业人员以外的暴露人群中的价值。
