Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium.
Biostatistics Unit, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium.
Viruses. 2022 Oct 26;14(11):2361. doi: 10.3390/v14112361.
In the SCOPE study, we monitored SARS-CoV-2 antibodies in a national sample of residents and staff from Belgian nursing homes. Here, we report the seroprevalence among infected and infection-naive residents and staff after the primary COVID-19 vaccination campaign. Among 1554 vaccinated nursing home residents and 1082 vaccinated staff from 69 nursing homes in Belgium, we assessed the proportion having SARS-CoV-2 antibodies approximately two (April 2021), four (June 2021), and six months (August 2021) after a two-dose regimen of the BNT162b2 vaccine. We measured the seroprevalence using SARS-CoV-2 antibody rapid tests and collected socio-demographic and COVID-19 medical data using an online questionnaire. Two months after vaccination (baseline), we found a seroprevalence of 91% (95% CI: 89-93) among vaccinated residents and 99% (95% CI: 98-99) among vaccinated staff. Six months after vaccination, the seroprevalence significantly decreased to 68% (95% CI: 64-72) among residents and to 89% (95% CI; 86-91) among staff ( < 0.001). The seroprevalence was more likely to decrease among infection-naive residents, older residents, or residents with a high care dependency level. These findings emphasize the need for close monitoring of nursing home residents, as a substantial part of this population fails to mount a persistent antibody response after BNT162b2 vaccination.
在 SCOPE 研究中，我们监测了来自比利时养老院居民和工作人员的全国样本中的 SARS-CoV-2 抗体。在这里，我们报告了在 COVID-19 初级疫苗接种运动后感染和无感染居民和工作人员的血清阳性率。在比利时 69 家养老院的 1554 名接种疫苗的养老院居民和 1082 名接种疫苗的工作人员中，我们评估了大约两剂 BNT162b2 疫苗接种后两个月（2021 年 4 月）、四个月（2021 年 6 月）和六个月（2021 年 8 月）时具有 SARS-CoV-2 抗体的比例。我们使用 SARS-CoV-2 抗体快速检测来测量血清阳性率，并使用在线问卷收集社会人口统计学和 COVID-19 医疗数据。接种疫苗两个月后（基线），我们发现接种疫苗的居民血清阳性率为 91%（95%CI：89-93），接种疫苗的工作人员为 99%（95%CI：98-99）。接种疫苗六个月后，居民的血清阳性率显著下降至 68%（95%CI：64-72），工作人员的血清阳性率下降至 89%（95%CI：86-91）（<0.001）。感染无血清阳性率的居民、年龄较大的居民或护理依赖程度较高的居民更有可能降低血清阳性率。这些发现强调了需要密切监测养老院居民，因为很大一部分人群在接种 BNT162b2 疫苗后未能产生持续的抗体反应。
