体外生理温度下新型关注变异株复制的差异。
Differences in New Variant of Concern Replication at Physiological Temperatures In Vitro.
机构信息
Division of Viral Products, Center for Biologics Evaluations and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
出版信息
J Infect Dis. 2023 Jan 11;227(2):202-205. doi: 10.1093/infdis/jiac264.
Abstract
Using multiple cell types and isolates of Delta and Omicron variants of SARS-CoV-2, we report differences in virus production, replication, and infectivity in vitro. Ancestral and Delta SARS-CoV-2 variant exhibit reduced virus production and replication at 34°C compared to 37°C while Omicron replication is balanced between temperatures.
摘要
使用来自 SARS-CoV-2 的 Delta 和奥密克戎变体的多种细胞类型和分离株，我们报告了病毒产量、复制和体外感染力的差异。与 37°C 相比，原始和 Delta SARS-CoV-2 变体在 34°C 时病毒产量和复制减少，而奥密克戎的复制在两种温度下平衡。
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