Sheik Samreen M, Bakthavatchalam Pugazhandhi, Shenoy Revathi P, Hadapad Basavaraj S, Nayak M Deepak, Biswas Monalisa, Bolar Suryakanth Varashree
Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Department of Anatomy, Melaka Manipal Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
J Ayurveda Integr Med. 2022 Jul-Sep;13(3):100583. doi: 10.1016/j.jaim.2022.100583. Epub 2022 Jun 24.
Ayurveda is a holistic system of medicine and describes a vast array of herbs and herbal mixtures that are been demonstrated to possess efficacy in research investigations. Guggulutikthaka gritha (GTG) is one such drug evaluated for its role in skin and bone diseases.
In the current study, the hypoglycemic, hypolipidemic, and anti-inflammatory effect of the drug GTG was studied with the scope to treat dyslipidemia and thereby reduce the risk of cardiovascular disease.
The animals (Wistar rats) were fed a high-fat diet and dyslipidemia was induced. The control group was provided with a normal chow diet and had free access to water. The treatment with the drug GTG was given for 21 days after confirming dyslipidemia. The blood glucose was measured immediately using a glucometer. The serum was analyzed for lipid profile and Vascular Cell Adhesion Molecule - 1(VCAM 1) by ELISA method before and after treatment. The histopathology of the heart and liver was also performed.
The abnormal change in lipid profile, blood glucose, and inflammatory marker along with the accumulation of intracellular fats in the arteries of the heart and liver confirmed dyslipidemia. A significant reduction in serum lipid profile (p < 0.05), blood glucose (p < 0.05), and VCAM 1 (p < 0.05) was noted after the treatment with significant histopathological changes in arteries of the heart and liver.
The study provides scientific validation on the drug GTG being effective in hyperglycemia, hyperlipidemia, and inflammation in dyslipidemia.
阿育吠陀是一种整体医学体系，描述了大量已在研究中证明具有疗效的草药和草药混合物。古古卢提卡塔卡酥油（GTG）就是这样一种针对其在皮肤和骨骼疾病中的作用进行评估的药物。
在本研究中，对药物GTG的降血糖、降血脂和抗炎作用进行了研究，旨在治疗血脂异常，从而降低心血管疾病风险。
给动物（Wistar大鼠）喂食高脂饮食以诱导血脂异常。对照组给予正常饲料饮食并可自由饮水。在确认血脂异常后，用药物GTG治疗21天。立即使用血糖仪测量血糖。通过ELISA法在治疗前后分析血清中的血脂谱和血管细胞粘附分子-1（VCAM 1）。还对心脏和肝脏进行了组织病理学检查。
血脂谱、血糖和炎症标志物的异常变化以及心脏和肝脏动脉中细胞内脂肪的积累证实了血脂异常。治疗后血清血脂谱（p < 0.05）、血糖（p < 0.05）和VCAM 1（p < 0.05）显著降低，心脏和肝脏动脉出现明显的组织病理学变化。
该研究为药物GTG对血脂异常中的高血糖、高血脂和炎症有效提供了科学验证。
