Vakiti Sakshika, Farriss Lessie, Mehta Hasrat, Madaram Meghana, Ferrigno Diana, Shoukry Rita, Arango Hipsley Jessica, Lee Bona, Atlas-Grayton Lian, Carlisano Celia, Petrosky Stephanie N
Osteopathic Medical School, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, USA.
Nutrition, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, USA.
Cureus. 2025 May 19;17(5):e84410. doi: 10.7759/cureus.84410. eCollection 2025 May.
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with no known cure in Western medicine. While steroids and other anti-inflammatory treatments help manage symptoms, Ayurvedic herbs and spices offer a holistic approach rooted in Ayurveda, an ancient Indian medical system that aims to balance life's forces (doshas) within the mind, body, and soul. Although certain Ayurvedic herbs have demonstrated anti-inflammatory properties, a comprehensive review of their efficacy in IBD treatment remains limited. This study evaluates the effectiveness of Ayurvedic herbal extracts and formulations in the treatment and prevention of IBD through a review of literature from January 2003 to September 2023 across Embase, PubMed, and Cochrane Central. A total of 25 full-text articles were analyzed, with data compiled based on study characteristics and relevance to the research question. Findings indicate macroscopic, microscopic, and clinically significant benefits, including reduced mucus in stool, improved colonic weight retention, and decreased inflammatory markers such as tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), prostaglandin E2 (PGE2), and endothelium-dependent relaxation (EDR). Clinically, patients reported fewer urgent bowel movements and an improved sense of well-being. These results suggest that Ayurvedic herbs may serve as a complementary or alternative therapy for IBD, warranting further well-designed clinical trials to fully assess their therapeutic potential.
炎症性肠病（IBD）是一种胃肠道的慢性炎症性疾病，西医尚无已知的治愈方法。虽然类固醇和其他抗炎治疗有助于控制症状，但阿育吠陀草药和香料提供了一种源自阿育吠陀的整体方法，阿育吠陀是一种古老的印度医学体系，旨在平衡思想、身体和灵魂中的生命力量（体液）。尽管某些阿育吠陀草药已显示出抗炎特性，但对其在IBD治疗中疗效的全面综述仍然有限。本研究通过回顾2003年1月至2023年9月期间Embase、PubMed和Cochrane Central上的文献，评估了阿育吠陀草药提取物和制剂在治疗和预防IBD方面的有效性。共分析了25篇全文文章，并根据研究特征和与研究问题的相关性汇总了数据。研究结果表明，在宏观、微观和临床上都有显著益处，包括粪便中黏液减少、结肠重量保留改善以及肿瘤坏死因子-α（TNF-α）、白细胞介素-2（IL-2）、前列腺素E2（PGE2）和内皮依赖性舒张（EDR）等炎症标志物减少。临床上，患者报告的紧急排便次数减少，幸福感增强。这些结果表明，阿育吠陀草药可能作为IBD的补充或替代疗法，需要进一步设计良好的临床试验来全面评估其治疗潜力。
