Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California.
G-Tech Medical, Fogarty Innovation, Mountain View, California.
J Surg Res. 2022 Nov;279:119-126. doi: 10.1016/j.jss.2022.05.012. Epub 2022 Jun 24.
Currently, there is no accurate noninvasive measurement system to diagnose gastrointestinal (GI) motility disorders. Wireless skin patches have been introduced to provide an accurate noninvasive measurement of GI myoelectric activity which is essential for developing neuro-stimulation devices to treat GI motility disorders. The aim of this study is to compare the external and internal electrical signal measurements in ambulatory pigs.
Yucatan pigs underwent placement of internal electrodes on the stomach, small intestine, and colon. Wires were brought through the abdominal wall. Signals were collected by a wireless receptor. Four external patches were placed on the abdominal skin to record the signals simultaneously. Pigs were kept for 6 d while the sensors were continuously recording the data from both systems.
Internal sensors detected rich signals from each organ. The stomach had a dominant frequency that ranged from 4 to 4.5 cpm, with occasional higher frequencies at 2, 3 and 4 times that. Small intestine signals had their primary energy in the 12-15 cpm range. Colon signals primarily displayed a dominant broad peak in the 4-6 cpm region. External skin patches detected a substantial fraction of the activities measured by the internal electrodes. A clear congruence in the frequency spectrum was observed between the internal and external readings.
Internally measured myoelectrical signals confirmed different patterns of rhythmic activity of the stomach, small intestine, and colon. Skin patches provided GI myoelectric measurement with a range of frequencies that could be useful in the diagnosis and treatment of motility disorders.
目前，尚无准确的非侵入性测量系统来诊断胃肠道（GI）运动障碍。无线皮肤贴片已被引入，以提供对 GI 肌电活动的准确非侵入性测量，这对于开发用于治疗 GI 运动障碍的神经刺激设备至关重要。本研究的目的是比较活动猪中外源和内源电信号的测量。
尤卡坦猪接受在胃、小肠和结肠内置入内部电极。导线通过腹壁引出。信号由无线接收器采集。四个外部贴片被放置在腹部皮肤上，同时记录两个系统的信号。猪被保留 6 天，传感器持续记录数据。
内部传感器从每个器官检测到丰富的信号。胃的主频范围为 4 至 4.5 cpm，偶尔会出现 2、3 和 4 倍的更高频率。小肠信号的主要能量范围在 12-15 cpm 之间。结肠信号主要在 4-6 cpm 区域显示主导宽峰。外部皮肤贴片检测到了内部电极测量的活动的很大一部分。在内部和外部读数之间观察到频谱的明显一致性。
内部测量的肌电信号证实了胃、小肠和结肠的不同节律性活动模式。贴片提供了广泛的 GI 肌电测量频率，这在运动障碍的诊断和治疗中可能有用。
