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关节结核的不常见部位——三例保守治疗病例系列。

An unusual site of articular tuberculosis-A series of three conservatively managed cases.

机构信息

Department of Pulmonary Medicine, Government Medical College, Patiala, India.

Department of Pulmonary Medicine, TB Hospital, Government Medical College, Patiala, India.

出版信息

Indian J Tuberc. 2022 Jul;69(3):359-363. doi: 10.1016/j.ijtb.2021.07.004. Epub 2021 Jul 13.

Abstract

Tuberculosis (TB) infection of the Sternoclavicular joint (SCJ) is a rare entity, with 1-2% of all osteo-articular cases reported. We report a series of three cases of TB of the SCJ, in the patients presented with swelling of SCJ. Cytology showed chronic granulomatous pathology in all three cases, with one patient having Cartridge base nucleic acid amplification test positive for TB and another one having acid fast bacilli positive on Ziehl Neelsen staining. All three were put on antitubercular treatment (ATT) that resulted in significant improvement. A high index of suspicion of TB to be maintained in cases with swellings at unusual sites especially in high burden countries like India. Similarly, gradually progressive osteoarticular swellings without systemic features should also raise suspicion of tubercular etiology, as diagnosis was delayed for about 4 months in two of our cases and about 1 year in the third case. The application of newer technologies such as CBNAAT can help in early microbiological confirmation of paucibacillary disease leading to early diagnosis and prevention of possible complications.

摘要

胸锁关节结核感染是一种罕见的疾病,约占所有骨关节炎病例的 1-2%。我们报告了三例胸锁关节结核病例,这些患者均表现为胸锁关节肿胀。细胞学检查显示三例均为慢性肉芽肿性病变,其中一例 Cartridge base nucleic acid amplification test 对结核分枝杆菌呈阳性,另一例 Ziehl Neelsen 染色抗酸杆菌阳性。所有三例均接受抗结核治疗(ATT),结果显著改善。在印度等高负担国家,对于发生在不常见部位的肿胀病例,应保持对结核的高度怀疑。同样,逐渐进展的骨关节肿胀而无全身症状也应怀疑结核病因,因为我们的两例病例的诊断延迟了约 4 个月,第三例病例则延迟了约 1 年。新型技术如 CBNAAT 的应用有助于早期对少菌性疾病进行微生物学确认,从而实现早期诊断和预防可能的并发症。

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