Hruby W, Stellamor K
Rontgenblatter. 1987 Mar;40(3):73-7.
Between January 1982 and May 1986 more than 50,000 patients were examined radiologically with water-soluble (ionic and nonionic) contrast media at the Department of Radiology Rudolfsstiftung, Vienna. In 1983 only 2.2% of the contrast agents used were nonionic, in 1985 the share had increased to 53.3%. During this period the rate of drug-related side effects (DRSE) decreased from 6.9% (1983) to 3.3% (1985). From 1983 to 1985 DRSE were observed with 1952 patients after administration of ionic agents, whereas after application of nonionic media adverse reactions occurred in only 6 cases, so that DRSE rates of 6.98% respectively 0.07% resulted for ionic respectively nonionic contrast media. These results are discussed with regard to the physicochemical properties und physiological actions of ionic and nonionic contrast agents.
1982年1月至1986年5月期间，维也纳鲁道夫基金会放射科对50000多名患者使用水溶性（离子型和非离子型）造影剂进行了放射学检查。1983年，所用造影剂中只有2.2%是非离子型的，到1985年，这一比例已增至53.3%。在此期间，药物相关副作用（DRSE）的发生率从1983年的6.9%降至1985年的3.3%。1983年至1985年期间，1952名患者在使用离子型造影剂后出现了DRSE，而使用非离子型造影剂后仅发生了6例不良反应，因此离子型和非离子型造影剂的DRSE发生率分别为6.98%和0.07%。结合离子型和非离子型造影剂的物理化学性质及生理作用对这些结果进行了讨论。
