Wang Dong-Dong, Jia Ming-Qian, Xu He-Li, Li Yu, Liu Jia-Xin, Liu Jia-Cheng, Sun Jia-Nan, Cao Fan, Wu Lang, Liu Fang-Hua, Li Yi-Zi, Wei Yi-Fan, Li Xiao-Ying, Xiao Qian, Gao Song, Huang Dong-Hui, Zhang Tao, Gong Ting-Ting, Wu Qi-Jun
Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China.
J Transl Med. 2025 Jan 30;23(1):134. doi: 10.1186/s12967-024-06041-6.
The evidence on the relationship of dietary antioxidant nutrients with the survival of ovarian cancer (OC) remains scarce.
This study aimed to investigate these associations in a prospective cohort of Chinese patients with OC.
In this prospective cohort study, patients with epithelial OC completed a food frequency questionnaire at diagnosis and 12 months post-diagnosis, and were followed from 2015 to 2023. Dietary total antioxidant capacity (TAC) and composite dietary antioxidant index (CDAI) were calculated based on specific antioxidant nutrients. We examined the associations of pre-diagnosis, post-diagnosis, and changes from pre-diagnosis to post-diagnosis in TAC, CDAI, and representative antioxidant nutrients with overall survival (OS) among patients with OC. Multivariable Cox proportional-hazards models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI). Dose-response relationships were evaluated by restricted cubic splines.
Among the total 560 patients with OC, there were 211 (37.68%) deaths during a median follow-up of 44.40 (interquartile range: 26.97-61.37) months. High pre-diagnosis TAC (HR = 0.58; 95% CI 0.38-0.8) and vitamin C intake (HR = 0.36; 95% CI 0.21-0.61), and post-diagnosis TAC (HR = 0.57; 95% CI 0.37-0.8), CDAI (HR = 0.57; 95% CI 0.33-0.9), and β-carotene intake (HR = 0.55; 95% CI 0.32-0.97) were significantly associated with improved OS. Compared to patients with constantly low pre- and post-diagnosis TAC and CDAI, those with consistently higher TAC (HR = 0.53; 95% CI 0.29-0.97; HR = 0.40; 95% CI 0.16-0.94) and CDAI (HR = 0.33; 95% CI 0.12-0.88) experienced better OS.
High pre- and post-diagnosis TAC, and post-diagnosis CDAI were associated with improved OC survival, suggesting that consistent high-intake of antioxidant-rich food may be beneficial for the prognosis of OC.
关于膳食抗氧化营养素与卵巢癌（OC）患者生存率之间关系的证据仍然很少。
本研究旨在对中国OC患者的前瞻性队列进行研究，以探讨这些关联。
在这项前瞻性队列研究中，上皮性OC患者在确诊时和确诊后12个月完成了一份食物频率问卷，并于2015年至2023年进行随访。根据特定抗氧化营养素计算膳食总抗氧化能力（TAC）和复合膳食抗氧化指数（CDAI）。我们研究了OC患者确诊前、确诊后以及从确诊前到确诊后TAC、CDAI和代表性抗氧化营养素的变化与总生存期（OS）之间的关联。应用多变量Cox比例风险模型计算风险比（HR）和95%置信区间（CI）。通过受限立方样条评估剂量反应关系。
在总共560例OC患者中，在中位随访44.40（四分位间距：26.97 - 61.37）个月期间有211例（37.68%）死亡。确诊前高TAC（HR = 0.58；95% CI 0.38 - 0.8）和维生素C摄入量（HR = 0.36；95% CI 0.21 - 0.61），以及确诊后TAC（HR = 0.57；95% CI 0.37 - 0.8）、CDAI（HR = 0.57；95% CI 0.33 - 0.9）和β-胡萝卜素摄入量（HR = 0.55；95% CI 0.32 - 0.97）与OS改善显著相关。与确诊前后TAC和CDAI持续较低的患者相比，TAC（HR = 0.53；95% CI 0.29 - 0.97；HR = 0.40；95% CI 0.16 - 0.94）和CDAI（HR = 0.33；95% CI 0.12 - 0.88）持续较高的患者OS更好。
确诊前后高TAC以及确诊后CDAI与OC生存率改善相关，这表明持续高摄入富含抗氧化剂的食物可能对OC的预后有益。
