Kittang E, Aadland E, Schjønsby H, Røhss K
Scand J Gastroenterol. 1987 Mar;22(2):156-60. doi: 10.3109/00365528708991873.
The effect of gastric anacidity on the absorption of food-bound cobalamins is uncertain. Omeprazole, an inhibitor of the enzyme H-K-ATPase in the parietal cell, is the most potent inhibitor of gastric acidity known so far. In 17 healthy male volunteers the absorption of liver-bound cobalamins was assessed after a single intravenous dose of omeprazole (80 mg) or placebo in a double-blind, crossover manner. The effect of omeprazole on pH, gastric acidity, and intrinsic factor (IF) concentration was measured in aspirates of gastric juice 5 min before and 30 and 60 min after the administration of liver homogenate containing 0.74 nmol of 57Co-labelled cobalamins. Omeprazole treatment resulted in anacidity (pH values above 6.0) in 14 individuals 30 min after the liver dose and in 15 individuals after 60 min. The IF concentration was unchanged in the omeprazole experiment as compared with the placebo experiment. The absorption of liver-bound cobalamins was 310 pmol (189-501 pmol) in the omeprazole experiment as compared with 415 pmol (150-549 pmol) in the placebo experiment (median values and range, p = 0.5228). We suggest that anacidity induced by omeprazole does not reduce the absorption of liver-bound cobalamins.
胃无酸对食物结合型钴胺素吸收的影响尚不确定。奥美拉唑是壁细胞中H-K-ATP酶的抑制剂，是目前已知最强的胃酸抑制剂。在17名健康男性志愿者中，采用双盲、交叉方式，单次静脉注射奥美拉唑（80毫克）或安慰剂后，评估肝脏结合型钴胺素的吸收情况。在给予含0.74纳摩尔57Co标记钴胺素的肝脏匀浆前5分钟以及给药后30分钟和60分钟，测量奥美拉唑对胃液pH值、胃酸度和内因子（IF）浓度的影响。在肝脏给药后30分钟，14名个体出现无酸（pH值高于6.0），60分钟后有15名个体出现无酸。与安慰剂实验相比，奥美拉唑实验中的IF浓度没有变化。奥美拉唑实验中肝脏结合型钴胺素的吸收量为310皮摩尔（189 - 501皮摩尔），而安慰剂实验中为415皮摩尔（150 - 549皮摩尔）（中位数和范围，p = 0.5228）。我们认为，奥美拉唑诱导的无酸状态不会降低肝脏结合型钴胺素的吸收。
