Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China.
Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China.
Mol Neurodegener. 2022 Jun 27;17(1):46. doi: 10.1186/s13024-022-00544-w.
A constant metabolism and energy supply are crucial to all organs, particularly the brain. Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are associated with alterations in cellular metabolism. These changes have been recognized as a novel hot topic that may provide new insights to help identify risk in the pre-symptomatic phase of the disease, understand disease pathogenesis, track disease progression, and determine critical endpoints. Nuclear receptor-related factor 1 (NURR1), an orphan member of the nuclear receptor superfamily of transcription factors, is a major risk factor in the pathogenesis of PD, and changes in NURR1 expression can have a detrimental effect on cellular metabolism. In this review, we discuss recent evidence that suggests a vital role of NURR1 in dopaminergic (DAergic) neuron development and the pathogenesis of PD. The association between NURR1 and cellular metabolic abnormalities and its implications for PD therapy have been further highlighted.
持续的新陈代谢和能量供应对所有器官都至关重要，尤其是大脑。与年龄相关的神经退行性疾病，如帕金森病（PD），与细胞代谢的改变有关。这些变化已被认为是一个新的热门话题，可能为帮助识别疾病的无症状前阶段的风险、了解疾病发病机制、跟踪疾病进展以及确定关键终点提供新的见解。核受体相关因子 1（NURR1）是核受体转录因子超家族的孤儿成员，是 PD 发病机制中的主要危险因素，NURR1 表达的变化可能对细胞代谢产生有害影响。在这篇综述中，我们讨论了最近的证据，表明 NURR1 在多巴胺能（DAergic）神经元发育和 PD 发病机制中起着至关重要的作用。还进一步强调了 NURR1 与细胞代谢异常的关联及其对 PD 治疗的意义。
