Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Curr Drug Saf. 2023;18(3):323-334. doi: 10.2174/1574886317666220627112353.
Aluminum phosphide (ALP) poisoning is considered one of the health care issues in Iran, which is associated with the mortality outcome of patients.
According to the ALP poisoning that commonly results in death, we aimed to evaluate the prevalence of ALP pill poisoning by employing register-based research.
In this descriptive cross-sectional study, all selected patients diagnosed and confirmed with ALP poisoning by a specialist and referred to the poisoning ward from the beginning of April 2016 to the end of October 2017 were enrolled, and data were registered in the Disease Registration System by a technical expert for daily follow-up during hospitalization.
Approximately 12.4% of patients had neurological problems, with the majority having paresis (68.3%). Self-poisoning with the purpose of suicide was documented for 96.2% of cases, with the most common cause being family problems (54.1%). In 97.3% of cases, the method of contact with the toxic substance was oral. Hypotension, cardiac, and respiratory complications were observed in 25.2%, 30.8%, and 25% of the patients, respectively. The most gastrointestinal symptoms were nausea and vomiting (86.7%).
The results indicate that the rate of ALP pill poisoning is relatively high. Suicide is the most important cause of ALP poisoning, which is more common in men under 40 years of age.
磷化铝（ALP）中毒被认为是伊朗的一个医疗保健问题之一，与患者的死亡率有关。
由于 ALP 中毒通常会导致死亡，我们旨在通过基于登记的研究来评估 ALP 药丸中毒的患病率。
在这项描述性的横断面研究中，我们招募了所有在 2016 年 4 月初至 2017 年 10 月底期间被专家诊断并确认 ALP 中毒并被转介到中毒病房的患者，数据由一名技术专家登记在疾病登记系统中，以便在住院期间进行日常随访。
约 12.4%的患者有神经系统问题，其中大多数有瘫痪（68.3%）。自杀是 96.2%病例的自我中毒目的，最常见的原因是家庭问题（54.1%）。在 97.3%的病例中，接触有毒物质的方法是口服。低血压、心脏和呼吸并发症分别在 25.2%、30.8%和 25%的患者中观察到。最常见的胃肠道症状是恶心和呕吐（86.7%）。
结果表明，ALP 药丸中毒的发生率相对较高。自杀是 ALP 中毒的最重要原因，40 岁以下的男性更为常见。
