School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China; Shaanxi Research Institute of Agricultural Products Processing Technology, Xi'an 710021, China.
School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China.
Food Res Int. 2022 Jul;157:111206. doi: 10.1016/j.foodres.2022.111206. Epub 2022 Apr 2.
Lipids in dairy products, as the crucial components in the most essential biological processes, were among the many nutrients delivered to the infants and adults. The structures of lipids are not only intricate but also varied, which makes the holistic and systematic analyses challenging. In recent years, lipidomics, as the new promoter of lipomics in the omics era, has become one of the fastest growing scientific disciplines in food science research. In addition, lipidomics is also one of the major methods to explore the dynamic changes and chemical compositions of lipids in dairy products in recent years. It is a relatively new frontier of intermolecular interactions research, using advanced liquid chromatography mass spectrometry technology to explore lipids. In this paper, the latest progress of liquid chromatography mass spectrometry based lipidomics was reviewed, with emphasis on the application of lipidomics and metabolic disease risk in dairy research. This includes a detailed workflow for routine lipidomics analysis, as well as examples of applications devoted dairy foods components, quality, safety, and revealing the health benefits of dairy products lipids. Advanced and effective methods of MS promote the in-depth study of gut microbiota and human metabolic disease risk and provide tangible solutions for further research in this field.
乳制品中的脂质是许多营养物质的重要组成部分，为婴儿和成年人提供了必需的生物过程所需的营养物质。脂质的结构不仅复杂而且多样化，这使得对其进行全面和系统的分析具有挑战性。近年来，脂质组学作为组学时代脂质组学的新推动者，已成为食品科学研究中发展最快的科学学科之一。此外，脂质组学也是近年来探索乳制品中脂质动态变化和化学成分的主要方法之一。它是研究分子间相互作用的相对较新的前沿领域，使用先进的液相色谱-质谱联用技术来探索脂质。本文综述了基于液相色谱-质谱联用的脂质组学的最新进展，重点介绍了脂质组学在乳制品研究中的应用和代谢性疾病风险。这包括常规脂质组学分析的详细工作流程，以及专门针对乳制品食品成分、质量、安全性的应用实例，并揭示了乳制品脂质的健康益处。MS 的先进有效的方法促进了对肠道微生物群和人类代谢性疾病风险的深入研究，并为该领域的进一步研究提供了切实可行的解决方案。
