College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.
Food Res Int. 2022 Jul;157:111352. doi: 10.1016/j.foodres.2022.111352. Epub 2022 May 16.
The present study investigated effects of the fermented goat milk (FGM) produced with a combination of Streptococcus salivarius subsp. thermophilus and Lactobacillus delbrueckii subsp. bulgaricus (SL) and with another one of SL as well as Bifidobacterium animalis subsp. lactis (SLB) on the internal environment in the large intestine of mice. Both the richness and the diversity of microbiota was the most abundant in SL group. SL, SLB and the control groups were clustered into three independent groups. At the phylum level, Firmicutes was the most abundant in all the groups, and Deferribacteres in SLB group was more abundant than in SL group. SL and SLB increased the proportions of 6 and 5 genera, respectively. Firmicutes was positively correlated with all the significantly different species but negative to Actinobacteria at the phylum level. SL and SLB both significantly decreased the levels of butyric and valeric acids. Either SL or SLB can significantly improve the structures of microbiota, and both of them significantly decreased the levels of butyric and valeric acids in the large intestine of mice. Certain microbiota negatively related to the levels of butyric and valeric acids. FGM produced with SL or SLB can effectively alter the microbialflora and the levels of SCFA in the large intestine of mice.
本研究调查了由唾液链球菌亚种。嗜热和乳杆菌德氏亚种。保加利亚（SL）和另一种 SL 以及动物双歧杆菌亚种。 lactis（SLB）发酵山羊奶（FGM）对小鼠大肠内环境的影响。SL 组的微生物丰富度和多样性最丰富。SL、SLB 和对照组聚类为三个独立的组。在门水平上，厚壁菌门在所有组中最丰富，而 SLB 组中的脱硫杆菌门比 SL 组更丰富。SL 和 SLB 分别增加了 6 和 5 个属的比例。厚壁菌门与所有显著不同的物种呈正相关，但与放线菌门呈负相关。SL 和 SLB 均显著降低了丁酸和戊酸的水平。无论是 SL 还是 SLB 都能显著改善微生物群的结构，并且都能显著降低小鼠大肠中丁酸和戊酸的水平。某些与丁酸和戊酸水平呈负相关的微生物群。由 SL 或 SLB 生产的 FGM 可以有效地改变小鼠大肠中的微生物群落和 SCFA 水平。
