Liu Z H, Fu C S, Li Z K, Chi Y C, Song Y F, Gao F M, Liu X T, Wei L X
Sci Sin B. 1986 Oct;29(10):1039-53.
This paper describes the results observed on 850 male Wistar rats for two years after intraperitoneal injection with 131I, 132I or 125I of different radioactivities. The incidence of thyroid malignant tumor was 45.8% when the dose absorbed by the thyroid gland was 7.8 Gy in the 131I groups, and even tumors of lung and soft tissue, and malfunction of kidney and immune organs could be elicited when the radioiodine was overdosed. Both 132I and 125I have their optimal carcinogenic dose ranges and optimal doses of carcinogenesis. As the dosage decreases to a certain level, a low-limit dose incapable of inducing cancers may be present. 131I induced mainly papillary and mixed type carcinomas, 132I chiefly follicular and undifferentiated type carcinomas, while 125I induced follicular and medullary carcinomas. The paper also discusses cytochemical DNA quantitative assays of different histological types of thyroid gland carcinomas, holding that reference to such data as decreasing serum T4, elevating serum TSH and CIC may be helpful for early diagnosis of thyroid carcinomas.
本文描述了850只雄性Wistar大鼠腹腔注射不同放射性活度的131I、132I或125I两年后的观察结果。在131I组中，当甲状腺吸收剂量为7.8 Gy时，甲状腺恶性肿瘤发生率为45.8%，当放射性碘过量时，甚至可引发肺和软组织肿瘤以及肾脏和免疫器官功能障碍。132I和125I都有其最佳致癌剂量范围和最佳致癌剂量。当剂量降低到一定水平时，可能存在不能诱发癌症的下限剂量。131I主要诱发乳头状和混合型癌，132I主要诱发滤泡型和未分化型癌，而125I诱发滤泡型和髓样癌。本文还讨论了不同组织学类型甲状腺癌的细胞化学DNA定量测定，认为参考血清T4降低、血清TSH和CIC升高的数据可能有助于甲状腺癌的早期诊断。
