不同血糖监测方法对血糖控制的影响：系统评价和荟萃分析。

Effect of Different Glucose Monitoring Methods on Bold Glucose Control: A Systematic Review and Meta-Analysis.

机构信息

Department of Radiotherapy, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, China.

Reproductive Medicine Center, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, China.

出版信息

Comput Math Methods Med. 2022 Jun 18;2022:2851572. doi: 10.1155/2022/2851572. eCollection 2022.

OBJECTIVE

To evaluate the effectiveness of different glucose monitoring methods on blood glucose control and the incidence of adverse events among patients with type 1 diabetes mellitus.

METHODS

Using the method of literature review, the databases PubMed, Cochrane, and Embase were retrieved to obtain relevant research literature, and the selected studies were analyzed and evaluated. This study used Cochrane software RevMan5.4 to statistically analyze all the data.

RESULTS

A total of 15 studies were included in this study, including 10 randomized controlled trials and 5 crossover design trials, with a total of 2071 patients. Meta-analysis results showed that continuous blood glucose monitoring (CGM) could significantly reduce the HbA1c level of patients, weighted mean difference (WMD) = -2.69, 95% confidence interval (CI) (-4.25, -1.14), and < 0.001 compared with self-monitoring of blood glucose (SMBG). Meanwhile, the incidence of severe hypoglycemia in the CGM group was significantly decreased, risk ratio (RR) = 0.52, 95% CI 0.35-0.77, and = 0.001. However, there was no statistical difference in the probability of diabetic ketoacidosis between CGM and SMBG groups, RR = 1.34, 95% CI 0.57-3.15, and = 0.5.

CONCLUSION

Continuous blood glucose monitoring is associated with lower blood glucose levels than the traditional blood glucose self-test method.

目的

评估不同血糖监测方法对 1 型糖尿病患者血糖控制和不良事件发生率的影响。

方法

采用文献回顾的方法，检索 PubMed、Cochrane 和 Embase 数据库，获取相关研究文献，并对入选研究进行分析评价。本研究采用 Cochrane 软件 RevMan5.4 对所有数据进行统计学分析。

结果

共纳入 15 项研究，包括 10 项随机对照试验和 5 项交叉设计试验，共 2071 例患者。Meta 分析结果显示，连续血糖监测（CGM）可显著降低患者的 HbA1c 水平，加权均数差（WMD）=-2.69，95%置信区间（CI）（-4.25，-1.14），＜0.001；与自我血糖监测（SMBG）相比，CGM 组严重低血糖的发生率显著降低，风险比（RR）=0.52，95%CI（0.35，0.77）， =0.001。然而，CGM 组与 SMBG 组糖尿病酮症酸中毒的发生概率无统计学差异，RR=1.34，95%CI（0.57，3.15）， =0.5。