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多糖膳食补充剂通过“肠-脑”轴改善高脂肪饮食诱导的认知功能障碍。

Dietary Supplement of . Polysaccharides Ameliorates Cognitive Dysfunction Induced by High Fat Diet via "Gut-Brain" Axis.

机构信息

Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.

School of Pharmacy, Southwest Medical University, Luzhou, People's Republic of China.

出版信息

Drug Des Devel Ther. 2022 Jun 20;16:1931-1945. doi: 10.2147/DDDT.S356934. eCollection 2022.

DOI:10.2147/DDDT.S356934
PMID:35762015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9232844/
Abstract

PURPOSE

. polysaccharides (ARPs) have been reported to exhibit multiple pharmacological activities including anti-inflammatory and anti-hyperglycemia. This study aims to investigate the effect of ARPs on cognitive dysfunction induced by high fat diet (HFD).

METHODS

Six-week-old male mice were treated with ARPs by dietary supplementation for 14 weeks. The effect of ARPs on cognitive function was determined by assessing the changes in spatial learning and memory ability, neurotrophic factors in hippocampus, inflammatory parameters, intestinal barrier integrity, and gut microbiota.

RESULTS

ARPs supplementation can effectively ameliorate cognitive dysfunction, decrease the phosphorylation levels of Tau protein in hippocampus. Meanwhile, the increased body weight, plasma glucose, total cholesterol, inflammatory factors induced by HFD were abolished by ARPs treatment. Furthermore, ARPs treatment restored the intestinal epithelial barrier as evidenced by upregulation of intestinal tight junction proteins. Additionally, ARPs supplementation significantly decreased the relative abundance of several bacteria genus such as , which may play regulatory roles in cognitive function.

CONCLUSION

These results suggest that ARPs might be a promising strategy for the treatment of cognitive dysfunction induced by HFD. Mechanistically, alleviation of cognitive dysfunction by ARPs might be associated with the "gut-brain" axis.

摘要

目的

从银耳中提取的多糖（ARPs）已被报道具有多种药理活性，包括抗炎和降血糖作用。本研究旨在探讨 ARPs 对高脂饮食（HFD）诱导的认知功能障碍的影响。

方法

6 周龄雄性小鼠通过饮食补充 ARPs 治疗 14 周。通过评估空间学习和记忆能力的变化、海马神经营养因子、炎症参数、肠道屏障完整性和肠道微生物群，来确定 ARPs 对认知功能的影响。

结果

ARPs 补充可有效改善认知功能障碍，降低海马 Tau 蛋白的磷酸化水平。同时，ARPs 治疗消除了 HFD 引起的体重增加、血浆葡萄糖、总胆固醇和炎症因子。此外，ARPs 治疗上调了肠道紧密连接蛋白，恢复了肠道上皮屏障。此外，ARPs 补充显著降低了几个细菌属的相对丰度，如 ，它们可能在认知功能中发挥调节作用。

结论

这些结果表明，ARPs 可能是治疗 HFD 诱导的认知功能障碍的一种有前途的策略。从机制上讲，ARPs 缓解认知功能障碍可能与“肠-脑”轴有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/93d4ef1bd6d5/DDDT-16-1931-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/e4a65e8c2501/DDDT-16-1931-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/826bf58a3203/DDDT-16-1931-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/90a5c6500b05/DDDT-16-1931-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/fec74b6d1d6d/DDDT-16-1931-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/456ccfc9673b/DDDT-16-1931-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/884bd7d25e73/DDDT-16-1931-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/dc782cd862e8/DDDT-16-1931-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/93d4ef1bd6d5/DDDT-16-1931-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/e4a65e8c2501/DDDT-16-1931-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/826bf58a3203/DDDT-16-1931-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/90a5c6500b05/DDDT-16-1931-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/fec74b6d1d6d/DDDT-16-1931-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/456ccfc9673b/DDDT-16-1931-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/884bd7d25e73/DDDT-16-1931-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/dc782cd862e8/DDDT-16-1931-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4b/9232844/93d4ef1bd6d5/DDDT-16-1931-g0008.jpg

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