Department of Pediatrics, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Curr Opin Clin Nutr Metab Care. 2022 May 1;25(3):209-215. doi: 10.1097/MCO.0000000000000834. Epub 2022 Mar 3.
Milk-derived extracellular vesicles (MDEVs) are nanovesicles that carry microRNA (miRNA) DNA, RNA, proteins and lipids. MDEVs have a potential of therapeutic targets, based on their properties and cargo profile. The present review summarizes recent studies on MDEVs, their cargo and potential role in mammalian development.
The detailed characterization of their miRNA cargo leads to the conclusion of their potential importance in the regulation of gene expression, immune function, development and infant growth.While their miRNAs are important regulatory elements and their profile expression was characterized in various mammalian milk sources, little is known about their effect on infant health and development. MiRNA activity in breast milk is likely influenced by the overall ecosystem of the early environment, including maternal characteristics, behaviors, and health.
MDEVs may have an important role in early child development and infant future health. Understanding benefits of MDEVs characteristics have potential role on gut maturation, immune system development and the prevention of metabolic disorders.
奶源性细胞外囊泡（MDEVs）是一种携带 microRNA（miRNA）、DNA、RNA、蛋白质和脂质的纳米囊泡。基于其特性和货物特征，MDEVs 具有治疗靶点的潜力。本综述总结了关于 MDEVs、其货物以及它们在哺乳动物发育中潜在作用的最新研究。
对其 miRNA 货物的详细特征分析得出结论，它们在基因表达、免疫功能、发育和婴儿生长的调控中具有重要作用。虽然它们的 miRNA 是重要的调节因子，其在各种哺乳动物乳源中的表达谱已被描述，但关于它们对婴儿健康和发育的影响知之甚少。母乳中的 miRNA 活性可能受到早期环境整体生态系统的影响，包括母体特征、行为和健康。
MDEVs 可能在儿童早期发育和婴儿未来健康中发挥重要作用。了解 MDEVs 特征的益处可能对肠道成熟、免疫系统发育和代谢紊乱的预防具有重要作用。
