Department of Internal Medicine, Division of Pulmonary Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Epigenomics. 2022 Jun;14(12):727-739. doi: 10.2217/epi-2022-0090. Epub 2022 May 31.
Breast milk-derived extracellular vesicle (EV) miRNAs may program child health outcomes associated with maternal asthma and atopy. The authors investigated associations between maternal asthma/atopy and EV miRNAs in the Programming of Intergenerational Stress Mechanisms cohort. Breast milk-derived EV miRNAs collected 6.1 ± 5.9 weeks postnatally (n = 80 mothers) were profiled using the TaqMan OpenArray Human MicroRNA Panel. The authors assessed associations using adjusted robust regression. Nine EV miRNAs were associated with asthma during pregnancy ( criteria: nominal p < 0.05; || >0.2). miR-1290 was associated with asthma and atopy during pregnancy (p < 0.05; || >0.2). Enriched Kyoto Encyclopedia of Genes and Genomes pathways included TGF-β signaling and extracellular matrix-receptor interaction (false discovery rate <0.05). In this study, maternal asthma and atopy were associated with breast milk-derived EV miRNAs. Additional studies are needed to understand whether EV miRNAs have direct effects on infant and child health.
母乳来源的细胞外囊泡 (EV) miRNA 可能会影响与母亲哮喘和特应性相关的儿童健康结果。作者在 Programming of Intergenerational Stress Mechanisms 队列中研究了母亲哮喘/特应性与 EV miRNA 之间的关联。 在产后 6.1 ± 5.9 周收集母乳来源的 EV miRNA（n = 80 位母亲），并使用 TaqMan OpenArray Human MicroRNA 试剂盒进行分析。作者使用调整后的稳健回归来评估关联。 有 9 种 EV miRNA 与怀孕期间的哮喘相关（标准：名义 p < 0.05；|| > 0.2）。miR-1290 与怀孕期间的哮喘和特应性相关（p < 0.05；|| > 0.2）。京都基因与基因组百科全书富集途径包括 TGF-β 信号和细胞外基质-受体相互作用（错误发现率 < 0.05）。 在这项研究中，母亲哮喘和特应性与母乳来源的 EV miRNA 有关。需要进一步研究以了解 EV miRNA 是否对婴儿和儿童的健康有直接影响。
