State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences, Changchun, 130022, China.
University of Science and Technology of China, Hefei, 230026, China.
Chem Commun (Camb). 2022 Jul 14;58(57):7924-7927. doi: 10.1039/d2cc02975h.
Here, we report Fe-based single-atom nanozymes, which were fabricated by embedding Fe atoms into N-doped hollow carbon spheres. The nanozymes (FeSA-HNCSB) exhibit the efficient catalytic generation of ROS in the tumor microenvironment (TME). They possess multiple enzyme-mimicking activities, including catalase-like, oxidase-like, and peroxidase-like activities. Furthermore, the FeSA-HNCSB nanozymes also exhibit good photothermal conversion efficiency in the near-infrared (NIR) region, making them potential candidates for photothermal therapy (PTT) and photothermal-enhanced catalytic therapy. This work provides a new paradigm for integrating parallel catalytic therapy and PTT to improve the effectiveness of tumor treatment.
在这里，我们报告了一种基于铁的单原子纳米酶，它是通过将铁原子嵌入氮掺杂的空心碳球中制备的。这种纳米酶（FeSA-HNCSB）在肿瘤微环境（TME）中能够有效地催化活性氧（ROS）的生成。它具有多种酶模拟活性，包括过氧化物酶样、氧化酶样和过氧化氢酶样活性。此外，FeSA-HNCSB 纳米酶在近红外（NIR）区域也表现出良好的光热转换效率，使其成为光热治疗（PTT）和光热增强催化治疗的潜在候选者。这项工作为整合并行催化治疗和 PTT 以提高肿瘤治疗效果提供了新的范例。
