Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, People's Republic of China.
Department of Radiology, Shenzhen Third People's Hospital, Longgang District, Shenzhen, Guangdong, People's Republic of China.
J Magn Reson Imaging. 2023 Feb;57(2):420-431. doi: 10.1002/jmri.28317. Epub 2022 Jun 28.
The characteristics of static functional network connectivity (sFNC) and dynamic FNC (dFNC) in neurologically asymptomatic patients undergoing maintenance hemodialysis are unknown. Elucidating these characteristics may improve our understanding of the mechanisms of neuropathological damage in these patients.
To explore the static and dynamic characteristics of FNC in neurologically asymptomatic patients undergoing maintenance hemodialysis and the relationship between FNC-related parameters with the neuropsychological scores and blood biomarkers.
Retrospective.
A total of 23 neurologically asymptomatic patients undergoing maintenance hemodialysis and 25 healthy controls matched for age, sex, and years of education.
FIELD STRENGTH/SEQUENCE: A 3.0 T MRI/functional MRI and three-dimensional-T1 structural imaging ASSESSMENT: Independent components; spatial map intensity; sFNC and dFNC strengths; and time attribute parameters (mean dwell time, fractional window, and number of transitions) were determined. Neuropsychological tests were performed. Blood biochemical tests were performed for the patients but not healthy controls.
Chi-squared test, one-sample t-test, two-sample t-test, partial correlation analysis, and family-wise error and false discovery rate correction. P < 0.05 denoted statistical significance.
Significant group differences in the strengths of sFNC and dFNC between networks were found. The sFNC strength between the visual and sensorimotor networks was significantly associated with the global cognitive function score (i.e. the Montreal Cognitive Assessment [MoCA]) (r = 0.606). The sFNC strength between the salience and default mode networks was significantly associated with anxiety scores (r = 0.458). In state 1, positive correlations were found between the mean dwell time and backward digital span task score (r = 0.562), fractional window and MoCA score (r = 0.576), and fractional window and backward digital span task score (r = 0.592).
Neurologically asymptomatic patients undergoing maintenance hemodialysis had defective sFNC and dFNC. Our results provide a new perspective on the mechanism of neuropathological damage in patients undergoing maintenance hemodialysis.
1 TECHNICAL EFFICACY: Stage 1.
维持性血液透析的无症状神经系统患者的静息功能网络连接（sFNC）和动态功能网络连接（dFNC）特征尚不清楚。阐明这些特征可能有助于我们理解这些患者神经病理学损伤的机制。
探讨维持性血液透析的无症状神经系统患者的静息和动态功能网络连接的特征，以及功能网络连接相关参数与神经心理学评分和血液生物标志物之间的关系。
回顾性研究。
共纳入 23 名接受维持性血液透析的无症状神经系统患者和 25 名年龄、性别和受教育年限相匹配的健康对照者。
场强/序列：3.0T MRI/功能 MRI 和三维 T1 结构成像
独立成分；空间图谱强度；sFNC 和 dFNC 强度；以及时间属性参数（平均停留时间、分数窗口和转换次数）。进行神经心理学测试。对患者进行血液生化测试，但健康对照组不进行。
卡方检验、单样本 t 检验、两样本 t 检验、偏相关分析和总体错误率和假发现率校正。P 值<0.05 表示有统计学意义。
发现网络之间的 sFNC 和 dFNC 强度存在显著的组间差异。视觉和感觉运动网络之间的 sFNC 强度与总体认知功能评分（即蒙特利尔认知评估量表 [MoCA]）显著相关（r=0.606）。显着性网络与默认模式网络之间的 sFNC 强度与焦虑评分显著相关（r=0.458）。在状态 1 下，平均停留时间与倒背数字广度任务评分（r=0.562）、分数窗口与 MoCA 评分（r=0.576）和分数窗口与倒背数字广度任务评分（r=0.592）之间存在正相关。
接受维持性血液透析的无症状神经系统患者存在 sFNC 和 dFNC 缺陷。我们的研究结果为维持性血液透析患者神经病理学损伤的机制提供了新的视角。
1 技术功效：阶段 1。
