da Silva Bruna Ramos, Rufato Sarah, Mialich Mirele S, Cruz Loris P, Gozzo Thais, Jordao Alceu A
Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo (USP), São Paulo, Brazil.
Nursing School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Nutr Cancer. 2022;74(10):3611-3622. doi: 10.1080/01635581.2022.2093388. Epub 2022 Jun 28.
Nutritional status can change in breast cancer patients after treatment. However, the metabolic implications of those alterations are poorly understood. We used a cross-sectional study design to compare body composition, lipids, glucose levels, and adiposity indices in breast cancer patients with a matched control and a healthy group. We recruited women who completed their chemotherapy (BC group) and compared them with a group of women without cancer age and body mass index-paired (MC group) and a group of healthy women (HC group). We estimated body composition by bioelectrical impedance analysis, physical function by handgrip strength, and food consumption by 24-hour food record. A blood sample was collected. We calculated visceral obesity indices (VAI and LAP) and insulin resistance-triglyceride glucose (TyG). Eighty-eight women were included (BC = 36, MC = 36, HC = 16). BC patients demonstrated worse phase angle values, nutritional risk index and lower handgrip strength. Additionally, according to the indices, BC had impairments in lipids, worse glucose levels, and elevated visceral fat adiposity and presented important unhealthy dietary patterns characterized by under-recommended protein consumption and higher caloric intake than the other groups. No differences were observed between both control groups. Further investigations are required to examine the underlying mechanisms and the potential longitudinal changes during surveillance.
乳腺癌患者治疗后的营养状况会发生变化。然而，这些改变的代谢影响却知之甚少。我们采用横断面研究设计，比较乳腺癌患者与匹配的对照组和健康组在身体成分、血脂、血糖水平和肥胖指数方面的差异。我们招募了完成化疗的女性（乳腺癌组），并将她们与一组年龄和体重指数匹配的无癌女性（匹配对照组）以及一组健康女性（健康组）进行比较。我们通过生物电阻抗分析评估身体成分，通过握力评估身体功能，并通过24小时饮食记录评估食物摄入量。采集血样。我们计算了内脏肥胖指数（VAI和LAP）以及胰岛素抵抗-甘油三酯葡萄糖（TyG）。共纳入88名女性（乳腺癌组 = 36名，匹配对照组 = 36名，健康组 = 16名）。乳腺癌患者的相位角值、营养风险指数较差，握力较低。此外，根据各项指数，乳腺癌患者存在血脂异常、血糖水平较差、内脏脂肪肥胖增加的情况，并且呈现出以蛋白质摄入量未达推荐标准以及热量摄入高于其他组为特征的重要不健康饮食模式。两个对照组之间未观察到差异。需要进一步研究以检查潜在机制以及监测期间的潜在纵向变化。
