University of Texas Medical Branch, Department of Microbiology and Immunology, Galveston, Texas, USA.
Microbiol Spectr. 2022 Aug 31;10(4):e0150622. doi: 10.1128/spectrum.01506-22. Epub 2022 Jun 28.
The Latin American Coalition for Escherichia coli Research (LACER) was created as a network of investigators using One Health approaches trying to understand infections caused by regional E. coli isolates and to sound the alarm due to the evolution of strains that are multiresistant to antibiotics (resistome) that also display different virulence profiles (virulome). After the COVID19 pandemic, a major concern by investigators has been the appearance of more virulent and resistant strains. Recently, a paper published in Microbiology Spectrum by Brazilian investigators (Fuga B., et al. Microbiol Spectr 10:e0125621, 2022, https://doi.org/10.1128/spectrum.01256-21) has used a genomic approach to demonstrate that during a period of 45 years, a wide resistome and virulome has converged, resulting in the appearance and persistence of high-risk clones affecting humans, animals and the environment, and its rapid dissemination is becoming an unattended international threat.
拉美产肠杆菌科研究联盟（LACER）是一个网络调查员组织，他们采用“One Health”方法来了解由地区性大肠杆菌分离株引起的感染，并对具有抗药性（耐药组）和不同毒力特征（毒力组）的进化菌株发出警报。在 COVID19 大流行之后，调查人员主要关注的是出现更具毒力和耐药性的菌株。最近，巴西研究人员在《微生物学光谱》杂志上发表了一篇论文（Fuga B.，et al. Microbiol Spectr 10:e0125621, 2022, https://doi.org/10.1128/spectrum.01256-21），该论文采用基因组方法证明，在 45 年的时间里，广泛的耐药组和毒力组已经趋同，导致影响人类、动物和环境的高风险克隆的出现和持续存在，其快速传播正在成为一个未被关注的国际威胁。
