Sirisinha S, Wongratanacheewin S
Southeast Asian J Trop Med Public Health. 1986 Dec;17(4):567-73.
Attempts were made to induce acquired immunity against Opisthorchis viverrini infection in hamsters by immunizing them with aqueous somatic extract and metabolic products of adult worms, crude adult worm homogenates and metacercarial somatic extracts via either the intraperitoneal or combined intraperitoneal and oral routes. These procedures failed to stimulate significant protective response in animals that had never been exposed to O. viverrini. However, the protective response reached a significant level (30% worm reduction) in hamsters that had been infected with a small member of flukes prior to immunization with aqueous somatic extract of adult worms. Although these findings indicate that it may be possible to reduce reinfection in people in the endemic area by immunization, it appears that a better method currently available for the control of O. viverrini infection is health education aimed at changing food habits and improving sanitation and personal hygiene.
用成虫的水溶性体提取物和代谢产物、成虫粗匀浆以及后尾蚴体提取物，经腹腔内或腹腔内与口服联合途径对仓鼠进行免疫。这些方法未能在从未接触过华支睾吸虫的动物中刺激产生显著的保护性反应。然而，在用成虫水溶性体提取物免疫之前已感染少量吸虫的仓鼠中，保护性反应达到了显著水平（虫体减少30%）。尽管这些发现表明通过免疫可能降低流行地区人群的再感染，但目前看来，控制华支睾吸虫感染的更好方法是开展健康教育，以改变饮食习惯、改善环境卫生和个人卫生。
