Cardiology Department, Hospital General Docente "Enrique Cabrera", Havana.
Cardiology Department, Hospital Provincial General "Camilo Cienfuegos Gorriarán" de Sancti Spíritus, Universidad de Ciencias Médicas de Sancti Spíritus, Sancti Spíritus.
Gac Med Mex. 2022;158(2):83-89. doi: 10.24875/GMM.M22000646.
The triglyceride-glucose (TyG) index is considered a new marker of insulin resistance, and is associated with the development of cardiovascular diseases.
To evaluate the capability of TyG index to predict in-hospital -mortality in patients with acute ST-elevation myocardial infarction.
Multicenter cohort study that enrolled 1123 patients included in the Cuban Registry of Acute Myocardial Infarction between January 2018 and June 2021.
TyG index optimal cutoff point to predict mortality was 8.96 (sensitivity, 65.2%; specificity, 62.0%; area under the curve; 0.636; p < 0.001). In-hospital mortality was significantly higher in the group with TyG index ≥ 8.96. The logistic regression analysis revealed that the TyG index was an independent mortality predictor (OR = 2.959; 95% CI = 1.457-6.010; p = 0.003). When the TyG index was included in the multivariate model, it increased its predictive capacity (area under the curve, 0.917, p < 0.001). Kaplan-Meier curves showed significant differences between patient groups (p < 0.001).
The TyG index constitutes an independent risk factor of in-hospital mortality in patients with acute ST-elevation myocardial infarction.
甘油三酯-葡萄糖（TyG）指数被认为是胰岛素抵抗的一个新标志物，与心血管疾病的发展有关。
评估 TyG 指数预测急性 ST 段抬高型心肌梗死患者住院死亡率的能力。
这是一项多中心队列研究，纳入了 2018 年 1 月至 2021 年 6 月期间古巴急性心肌梗死注册研究中的 1123 例患者。
TyG 指数预测死亡率的最佳截断点为 8.96（敏感性为 65.2%，特异性为 62.0%，曲线下面积为 0.636，p<0.001）。TyG 指数≥8.96 组的住院死亡率显著更高。逻辑回归分析显示，TyG 指数是独立的死亡率预测因素（OR=2.959；95%CI=1.457-6.010；p=0.003）。当 TyG 指数被纳入多变量模型时，它增加了预测能力（曲线下面积为 0.917，p<0.001）。Kaplan-Meier 曲线显示了患者组之间的显著差异（p<0.001）。
TyG 指数是急性 ST 段抬高型心肌梗死患者住院死亡率的独立危险因素。
