Li Xin, Luan Ting, Wei Yi, Zhang JuanJuan, Zhao Chun, Ling Xiufeng
Department of Reproductive Medicine, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, 123 Tianfeixiang, Mochou Road, Qinhuai District, Nanjing, JiangSu, China.
Department of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.
J Ovarian Res. 2024 Apr 26;17(1):90. doi: 10.1186/s13048-024-01416-1.
Polycystic Ovary Syndrome (PCOS) is a common reproductive disorder that frequently affects fertility. The TyG-BMI (Triglyceride glucose-body mass) index is a newly explored parameter that may be linked to reproductive results in individuals with PCOS. Nevertheless, its connection with outcomes in In Vitro Fertilization (IVF) procedures remains uncertain.
This study included a total of 966 females who underwent IVF treatments for PCOS. At the baseline, the participants were categorized into four groups according to the quartiles of TyG-BMI measured prior to oocyte retrieval. Subsequently, the study compared the differences in clinical and laboratory outcomes among these four groups.
Patients in higher TyG-BMI quartiles exhibited a decreased number of retrieved oocytes, 2PN embryos, and available/high-quality embryos (P < 0.05 for Q1-Q4). Additionally, the multivariable regression analysis revealed that individuals in the top quartile of TyG-BMI had a lower count of accessible embryos (β = -0.224, P = 0.257) and a decreased number of high-quality embryos (β = -0.352, P = 0.028) in comparison to those in the lowest quartile. Nevertheless, there were no notable variances detected in the rates of pregnancy or live births among these quartiles. Furthermore, a linear correlation was noted between the TyG-BMI index and the quantity of accessible embryos (P-non-linear = 0.6, P-overall < 0.001), along with high-quality embryos (P-nonlinear = 0.026, P-overall = 0.006). In contrast, there was no notable linear correlation found between the TyG-BMI index and the available embryo rate (P-nonlinear = 0.60, P-overall = 0.8).
The results of this research emphasize the notable correlation between TyG-BMI and IVF results in females diagnosed with PCOS. The interplay of insulin resistance and disorders of lipid metabolism may indeed play a pivotal role in influencing the assisted reproductive outcomes of patients with PCOS. Considering these findings, TyG-BMI proves to be a valuable indicator for exploring this potential association.
多囊卵巢综合征（PCOS）是一种常见的生殖系统疾病，经常影响生育能力。甘油三酯葡萄糖-体重指数（TyG-BMI）是一个新探索的参数，可能与PCOS患者的生殖结果有关。然而，其与体外受精（IVF）程序结果的关联仍不确定。
本研究共纳入966名接受PCOS-IVF治疗的女性。在基线时，根据取卵前测量的TyG-BMI四分位数将参与者分为四组。随后，研究比较了这四组在临床和实验室结果方面的差异。
TyG-BMI四分位数较高的患者取出的卵母细胞、2PN胚胎以及可用/高质量胚胎数量减少（Q1-Q4，P<0.05）。此外，多变量回归分析显示，与最低四分位数的个体相比，TyG-BMI最高四分位数的个体可获得的胚胎数量较少（β=-0.224，P=0.257），高质量胚胎数量减少（β=-0.352，P=0.028）。然而，这些四分位数之间在妊娠率或活产率方面未检测到显著差异。此外，TyG-BMI指数与可获得的胚胎数量（P-非线性=0.6，P-总体<0.001）以及高质量胚胎数量（P-非线性=0.026，P-总体=0.006）之间存在线性相关性。相比之下，TyG-BMI指数与可用胚胎率之间未发现显著的线性相关性（P-非线性=0.60，P-总体=0.8）。
本研究结果强调了TyG-BMI与诊断为PCOS的女性IVF结果之间的显著相关性。胰岛素抵抗和脂质代谢紊乱的相互作用可能确实在影响PCOS患者的辅助生殖结果中起关键作用。考虑到这些发现，TyG-BMI被证明是探索这种潜在关联的一个有价值的指标。
