Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Anesthesiology, Social Security Organization Hospital, Ardabil, Iran.
J Health Popul Nutr. 2022 Jun 28;41(1):26. doi: 10.1186/s41043-022-00305-x.
This study aimed to determine the prevalence and antibiotic resistance patterns in Staphylococcus aureus isolated from patients with cystic fibrosis in Middle Eastern countries.
A systematic search was conducted in the PubMed, Web of Science (ISI), and Scopus databases for studies presenting the prevalence of MRSA strains, antibiotic resistance pattern in S. aureus strains isolated from patients who suffered from cystic fibrosis in Middle Eastern countries from 1999 to 10 June 2020. The following terms were used; prevalence, antibiotic resistance, antimicrobial drug resistance, drug resistance, Staphylococcus aureus, S. aureus, Methicillin-resistant Staphylococcus aureus, MRSA, cystic fibrosis, CF, and the Middle East. The meta-analysis was performed using Comprehensive Meta-analysis software (Version 3.3.070).
Patients' age ranged from 1.6 to 18 years. Females were more than males. The prevalence of S. aureus was varied between 5.6 and 77.8%. The prevalence of S. aureus was varied between 5.6 and 77.8% in different countries. The combined prevalence of S. aureus in Middle East countries from 1999 to 2020 was reported by 40.9% (95% CI 29.6-53.1). The pooled prevalence of MRSA was reported at 18.6% (95% CI 1.1-82.6), Z = 0.9, I = 98.6, Q = 146.7. The highest combined resistance in S. aureus strains was reported to Penicillin G (94%), followed by Ciprofloxacin (54.9%).
Regarding a quite prevalence of S. aureus and an intermediate prevalence of MRSA in CF patients, preventive measures and health policies should be implemented in the Middle East area to prevent the spread of infections caused by MRSA strains in CF patients.
本研究旨在确定中东国家囊性纤维化患者分离的金黄色葡萄球菌的流行率和抗生素耐药模式。
从 1999 年至 2020 年 10 月 10 日，在 PubMed、Web of Science（ISI）和 Scopus 数据库中系统地检索了报道中东国家囊性纤维化患者分离的金黄色葡萄球菌中 MRSA 株的流行率、抗生素耐药模式的研究。使用了以下术语；流行率、抗生素耐药性、抗微生物药物耐药性、耐药性、金黄色葡萄球菌、金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌、MRSA、囊性纤维化、CF 和中东。使用 Comprehensive Meta-analysis 软件（版本 3.3.070）进行荟萃分析。
患者年龄在 1.6 至 18 岁之间。女性多于男性。不同国家金黄色葡萄球菌的流行率在 5.6%至 77.8%之间不等。不同国家金黄色葡萄球菌的流行率在 5.6%至 77.8%之间不等。1999 年至 2020 年中东国家金黄色葡萄球菌的综合流行率为 40.9%（95%可信区间 29.6-53.1）。报告的 MRSA 总流行率为 18.6%（95%可信区间 1.1-82.6），Z=0.9，I=98.6，Q=146.7。金黄色葡萄球菌菌株的最高联合耐药性报道为青霉素 G（94%），其次是环丙沙星（54.9%）。
鉴于 CF 患者金黄色葡萄球菌的相当流行率和中间流行率的 MRSA，应在中东地区实施预防措施和卫生政策，以防止 CF 患者中由 MRSA 菌株引起的感染传播。
