Li Qiheng, Zhang Chunmei, Li Zhengjin
Department of Pathology, The First Affiliated Hospital of Dali University, Dali, Yunnan 671000, P.R. China.
Oncol Lett. 2022 Jun 14;24(2):255. doi: 10.3892/ol.2022.13375. eCollection 2022 Aug.
Solitary fibrous tumors/hemangiopericytomas (SFTs/HPCs) are intracranial spindle cell tumors that originate from interstitial tissue. SFTs/HPCs that are primary malignant intracranial tumors are exceedingly uncommon. A case of intracranial malignant SFT/HPC that originated intracranially and spread to the pulmonary region is described herein. Furthermore, the specimens from two surgical resections obtained when the patient had undergone two prior procedures for intracranial 'meningiomas' were also reviewed. The results of the lung biopsy matched the morphologic appearance of the intracranial tumor. The patient died ~2 years after the chest pain started. In addition, the literature was reviewed. According to previous studies, STAT6 expression was positive in 100% of SFTs/HPCs and radiologic characteristics assisted in determining the tumor pathology and grade. Surgical management has been the mainstay treatment for SFTs. In cases of incomplete resection, adjuvant radiotherapy is effective and rigorous follow-up is required to monitor for recurrence.
孤立性纤维瘤/血管外皮细胞瘤（SFTs/HPCs）是起源于间质组织的颅内梭形细胞瘤。原发性恶性颅内SFTs/HPCs极为罕见。本文描述了一例颅内原发并扩散至肺部区域的恶性颅内SFT/HPC病例。此外，还回顾了该患者在先前因颅内“脑膜瘤”接受两次手术时获得的两份手术切除标本。肺活检结果与颅内肿瘤的形态学表现相符。患者在胸痛开始约2年后死亡。另外，还对文献进行了回顾。根据先前的研究，100%的SFTs/HPCs中STAT6表达呈阳性，放射学特征有助于确定肿瘤病理及分级。手术治疗一直是SFTs的主要治疗方法。在不完全切除的病例中，辅助放疗有效，且需要严格随访以监测复发情况。
