Omura Akiisa, Kimura Toru, Maniwa Tomohiro, Watabe Tadashi, Honma Keiichiro, Shintani Yasushi, Okami Jiro
Department of General Thoracic Surgery, Osaka International Cancer Institute, Osaka, Japan.
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2-L5, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Surg Today. 2025 Mar 24. doi: 10.1007/s00595-025-03024-y.
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP) is a serine protease, overexpressed in various cancers, which has been explored as a diagnostic and therapeutic target. We analyzed patients who underwent resection of an intrathoracic SFT, including metastatic pulmonary nodules from extrathoracic organs.
The subjects of this retrospective study were seven patients with a primary SFT and two with metastatic SFTs in the lungs. After immunohistochemical staining of the resected tumors, quantification of the stained area was performed using QuPath.
Immunohistochemical quantification of FAP showed that it was expressed to varying degrees in the intrathoracic SFTs, with higher expression levels observed in metastatic SFTs than in primary pleural SFTs. Pathological examination confirmed the expression of FAP.
Our results support the potential usefulness of FAP in the diagnosis of intrathoracic SFTs, including metastatic pulmonary nodules.
孤立性纤维瘤（SFTs）是一种罕见的间叶性肿瘤，可发生于胸膜。过去，SFTs被认为是良性的，但已有报道称SFTs具有高度恶性。成纤维细胞活化蛋白（FAP）是一种丝氨酸蛋白酶，在多种癌症中过表达，已被探索作为诊断和治疗靶点。我们分析了接受胸腔内SFT切除的患者，包括来自胸外器官的转移性肺结节患者。
本回顾性研究的对象为7例原发性SFT患者和2例肺部转移性SFT患者。对切除的肿瘤进行免疫组织化学染色后，使用QuPath对染色区域进行定量分析。
FAP的免疫组织化学定量分析表明，其在胸腔内SFTs中呈不同程度表达，转移性SFTs中的表达水平高于原发性胸膜SFTs。病理检查证实了FAP的表达。
我们的结果支持FAP在胸腔内SFTs诊断中的潜在应用价值，包括转移性肺结节。
