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2
Is There a Role for Immunotherapy in Prostate Cancer?免疫疗法在前列腺癌中有作用吗？
Cells. 2020 Sep 8;9(9):2051. doi: 10.3390/cells9092051.
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Nanotreatment and Nanodiagnosis of Prostate Cancer: Recent Updates.前列腺癌的纳米治疗与纳米诊断：最新进展
Nanomaterials (Basel). 2020 Aug 28;10(9):1696. doi: 10.3390/nano10091696.
4
Effect of Atorvastatin, Curcumin, and Quercetin on miR-21 and miR-122 and their correlation with TGFβ1 expression in experimental liver fibrosis.阿托伐他汀、姜黄素和槲皮素对实验性肝纤维化中 miR-21 和 miR-122 的影响及其与 TGFβ1 表达的相关性。
Life Sci. 2020 Oct 15;259:118293. doi: 10.1016/j.lfs.2020.118293. Epub 2020 Aug 18.
5
Combination of Rapamycin and MK-2206 Induced Cell Death Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines.雷帕霉素与MK-2206联合诱导MYCN扩增的神经母细胞瘤细胞系发生细胞死亡、自噬和坏死性凋亡。
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6
Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells.Akt 抑制剂 MK-2206 对胶质母细胞瘤细胞迁移和辐射敏感性的差异影响。
BMC Cancer. 2019 Apr 3;19(1):299. doi: 10.1186/s12885-019-5517-4.
7
The Contributions of Prostate Cancer Stem Cells in Prostate Cancer Initiation and Metastasis.前列腺癌干细胞在前列腺癌起始和转移中的作用
Cancers (Basel). 2019 Mar 27;11(4):434. doi: 10.3390/cancers11040434.
8
Obesity, Inflammation, and Prostate Cancer.肥胖、炎症与前列腺癌
J Clin Med. 2019 Feb 6;8(2):201. doi: 10.3390/jcm8020201.
9
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Cell. 2019 Feb 7;176(4):831-843.e22. doi: 10.1016/j.cell.2019.01.025.
10
[The role of chemotherapy in the treatment of hormone sensitive metastatic prostate cancer.].[化疗在激素敏感性转移性前列腺癌治疗中的作用。]
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评估MK-2206与沙利霉素单独及联合使用对前列腺癌细胞系的影响。

Evaluating the Effects of Separate and Concomitant Use of MK-2206 and Salinomycin on Prostate Cancer Cell Line.

作者信息

Savaee Mohamadreza, Bakhshi Ali, Yaghoubi Fatemeh, Pourrajab Fatemeh, Goodarzvand Chegini Koorosh

机构信息

Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

出版信息

Rep Biochem Mol Biol. 2022 Apr;11(1):157-165. doi: 10.52547/rbmb.11.1.157.

DOI:10.52547/rbmb.11.1.157
PMID:35765523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9208569/
Abstract

BACKGROUND

Prostate cancer is known as one of the most prevalent health disorders in the male population globally. The aim of the current study was to evaluate the effects of separate and concomitant use of MK-2206 and salinomycin on prostate cancer cell line.

METHODS

The antitumor potential of separate and concomitant use of MK-2206 and salinomycin was evaluated in a panel of prostate cancer cell line (PC-3). To get insights into the underlying mechanism of action, different assays including the rate of apoptosis, cell viability, and gene expression were performed in treated prostate cancer cells.

RESULTS

A significant reduction was detected in the viability percentage of prostate cancer cells (p< 0.001) and the rate of Akt expression (p< 0.001) in all salinomycin, MK-2206, and salinomycin+MK-2206 groups compared to the negative control group. Furthermore, in comparison with the negative control group, there was a notable increase in both the rate of Bad expression (p< 0.001) and prostate cancer cells apoptosis after salinomycin, MK-2206, and salinomycin+MK-2206 treatments. Moreover, the concomitant use of salinomycin+MK-2206 revealed synergistic improvements regarding the viability of prostate cancer cells and the rate of the Akt and Bad expressions compared to the separate administration of salinomycin and MK-2206 (all p< 0.05).

CONCLUSION

The findings of the present study may contribute to improving the efficacy of the therapies regarding the management of prostate cancer and providing a beneficial strategy in clinical trials.

摘要

背景

前列腺癌是全球男性人群中最普遍的健康疾病之一。本研究的目的是评估MK-2206和沙林霉素单独及联合使用对前列腺癌细胞系的影响。

方法

在一组前列腺癌细胞系（PC-3）中评估MK-2206和沙林霉素单独及联合使用的抗肿瘤潜力。为深入了解其潜在作用机制，对经处理的前列腺癌细胞进行了包括凋亡率、细胞活力和基因表达在内的不同检测。

结果

与阴性对照组相比，所有沙林霉素、MK-2206以及沙林霉素+MK-2206组的前列腺癌细胞活力百分比（p<0.001）和Akt表达率（p<0.001）均显著降低。此外，与阴性对照组相比，沙林霉素、MK-2206以及沙林霉素+MK-2206处理后，Bad表达率（p<0.001）和前列腺癌细胞凋亡率均显著增加。而且，与单独使用沙林霉素和MK-2206相比，沙林霉素+MK-2206联合使用在前列腺癌细胞活力以及Akt和Bad表达率方面显示出协同改善作用（所有p<0.05）。

结论

本研究结果可能有助于提高前列腺癌治疗的疗效，并为临床试验提供有益的策略。