• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Gene-Gene Interaction Study Between Genetic Polymorphisms of Folate Metabolism and MTR SNPs on Prognostic Features Impact for Breast Cancer.叶酸代谢基因多态性与MTR单核苷酸多态性之间的基因-基因相互作用研究对乳腺癌预后特征的影响
Rep Biochem Mol Biol. 2022 Apr;11(1):89-101. doi: 10.52547/rbmb.11.1.89.
2
Strong Correlation of MTHFR Gene Polymorphisms with Breast Cancer and its Prognostic Clinical Factors among Egyptian Females.埃及女性中MTHFR基因多态性与乳腺癌及其预后临床因素的强相关性。
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):617-626. doi: 10.31557/APJCP.2021.22.2.617.
3
Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study.在摩洛哥人群中，ERCC2 和 MTHR 多态性与乳腺癌易感性之间存在显著关联：病例对照研究中的基因型和单倍型分析。
BMC Cancer. 2018 Mar 15;18(1):292. doi: 10.1186/s12885-018-4214-z.
4
Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in breast cancer risk in a population in Northeast Brazil.MTHFR C677T 和 A1298C 与 MTR A2756G 基因多态性在巴西东北部人群乳腺癌发病风险中的交互作用。
Anticancer Res. 2012 Nov;32(11):4805-11.
5
Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: A case-control study.中国汉族人群叶酸代谢基因多态性与胃癌易感性的关联研究：一项病例对照研究。
Mol Genet Genomic Med. 2019 May;7(5):e633. doi: 10.1002/mgg3.633. Epub 2019 Mar 18.
6
Methylene tetrahydrofolate reductase and methionine synthase gene polymorphisms as genetic determinants of pre-eclampsia.亚甲基四氢叶酸还原酶和蛋氨酸合成酶基因多态性作为子痫前期的遗传决定因素。
Pregnancy Hypertens. 2020 Apr;20:7-13. doi: 10.1016/j.preghy.2020.02.001. Epub 2020 Feb 10.
7
MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women.亚甲基四氢叶酸还原酶多态性、叶酸饮食摄入与中国女性乳腺癌风险。
J Hum Genet. 2009 Jul;54(7):414-8. doi: 10.1038/jhg.2009.57. Epub 2009 Jun 26.
8
One-carbon metabolism-related gene polymorphisms and risk of breast cancer.一碳代谢相关基因多态性与乳腺癌风险
Carcinogenesis. 2008 Feb;29(2):356-62. doi: 10.1093/carcin/bgm295. Epub 2008 Jan 3.
9
Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.叶酸、维生素B6和维生素B12的膳食摄入量、相关酶的基因多态性与乳腺癌风险：巴西女性的一项病例对照研究。
BMC Cancer. 2009 Apr 24;9:122. doi: 10.1186/1471-2407-9-122.
10
Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study.中国高血压人群中叶酸、同型半胱氨酸与MTHFR、MTR和MTRR基因多态性与血脂异常的联合关联：一项横断面研究
Lipids Health Dis. 2015 Sep 4;14:101. doi: 10.1186/s12944-015-0099-x.

引用本文的文献

1
Evaluation of tumorigenesis-related miRNAs in breast cancer in Egyptian women: a retrospective, exploratory analysis.评估埃及女性乳腺癌相关的肿瘤生成 miRNA：回顾性、探索性分析。
Sci Rep. 2024 Nov 29;14(1):29757. doi: 10.1038/s41598-024-68758-0.
2
Molecular and Immunohistochemical Alterations in Breast Cancer Patients in Upper Egypt.埃及上埃及地区乳腺癌患者的分子与免疫组化改变
Rep Biochem Mol Biol. 2023 Jan;11(4):532-546. doi: 10.52547/rbmb.11.4.532.

本文引用的文献

1
Correlation between and Polymorphisms and the Susceptibility to Breast Cancer.[基因名称1]和[基因名称2]多态性与乳腺癌易感性之间的相关性。 （你提供的原文中“and”前后缺少具体内容，请补充完整以便能更准确翻译）
Rep Biochem Mol Biol. 2020 Oct;9(3):291-296. doi: 10.29252/rbmb.9.3.291.
2
Strong Correlation of MTHFR Gene Polymorphisms with Breast Cancer and its Prognostic Clinical Factors among Egyptian Females.埃及女性中MTHFR基因多态性与乳腺癌及其预后临床因素的强相关性。
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):617-626. doi: 10.31557/APJCP.2021.22.2.617.
3
Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project.常见的 MTHFR 677C→T 多态性对成年人血压的影响以及核黄素在修饰高血压遗传风险中的作用：来自 JINGO 项目的证据。
BMC Med. 2020 Nov 11;18(1):318. doi: 10.1186/s12916-020-01780-x.
4
Association Analysis of Methylenetetrahydrofolate Reductase Common Gene Polymorphisms with Breast Cancer Risk in an Iranian Population: A Case-Control Study and a Stratified Analysis.亚甲基四氢叶酸还原酶常见基因多态性与伊朗人群乳腺癌风险的关联分析：病例对照研究和分层分析。
Asian Pac J Cancer Prev. 2020 Sep 1;21(9):2709-2714. doi: 10.31557/APJCP.2020.21.9.2709.
5
Relationship between methylenetetrahydrofolate reductase (MTHFR) gene (A1298C) polymorphism with the risk of stroke: A systematic review and meta-analysis.亚甲基四氢叶酸还原酶（MTHFR）基因（A1298C）多态性与卒中风险的关系：系统评价和荟萃分析。
Neurol Res. 2020 Nov;42(11):913-922. doi: 10.1080/01616412.2020.1798107. Epub 2020 Jul 29.
6
Gene Polymorphisms Prevalence and Cardiovascular Risk Factors Involved in Cardioembolic Stroke Type and Severity.基因多态性的患病率及与心源性栓塞性卒中类型和严重程度相关的心血管危险因素
Brain Sci. 2020 Jul 24;10(8):476. doi: 10.3390/brainsci10080476.
7
MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia.MTHFR、XRCC1 和 OGG1 基因多态性与乳腺癌的关系：来自撒丁岛北部人群的病例对照研究。
BMC Cancer. 2020 Mar 19;20(1):234. doi: 10.1186/s12885-020-06749-w.
8
Single nucleotide polymorphism of rs1801133 associated with elevated Hcy levels affects susceptibility to cerebral small vessel disease.与同型半胱氨酸水平升高相关的rs1801133单核苷酸多态性影响脑小血管病的易感性。
PeerJ. 2020 Feb 20;8:e8627. doi: 10.7717/peerj.8627. eCollection 2020.
9
Association of genes and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region.巴西亚马逊地区人群中基因和叶酸代谢途径与急性淋巴细胞白血病的关联
Leuk Res Rep. 2019 Nov 27;13:100188. doi: 10.1016/j.lrr.2019.100188. eCollection 2020.
10
Association of Two Methylenetetrahydrofolate Reductase Polymorphisms (rs1801133, rs1801131) with the Risk of Type 2 Diabetes in South-East of Iran.伊朗东南部两种亚甲基四氢叶酸还原酶多态性（rs1801133、rs1801131）与2型糖尿病风险的关联
Rep Biochem Mol Biol. 2019 Jul;8(2):178-183.

叶酸代谢基因多态性与MTR单核苷酸多态性之间的基因-基因相互作用研究对乳腺癌预后特征的影响

Gene-Gene Interaction Study Between Genetic Polymorphisms of Folate Metabolism and MTR SNPs on Prognostic Features Impact for Breast Cancer.

作者信息

Omran Moataza Hassan, Fotouh Basma El-Sayed, Shosha Wafaa Ghoneim, Ismail Abeer, Ramadan Shimaa Shawki

机构信息

Microbial Biotechnology Department, Genetic Engineering Division, National Research Centre, Cairo, Egypt (12622).

Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt (11795).

出版信息

Rep Biochem Mol Biol. 2022 Apr;11(1):89-101. doi: 10.52547/rbmb.11.1.89.

DOI:10.52547/rbmb.11.1.89
PMID:35765535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9208558/
Abstract

BACKGROUND

Breast Cancer (BC), the second leading cause of cancer mortality after lung cancer and varied across the world due to genetic and environmental factors. In this study, we evaluated the interaction between the polymorphisms in genes encoding enzymes of folate metabolism: methylenetetrahydrofolate reductase (), methionine synthesis reductase () with the BC prognostic factors.

METHODS

This study was conducted on 160 Egyptian subjects, 60 controls and 100 cases. Sequencing, RFLP analysis in addition to statistical analysis including Chi-squared test, haplotype analysis was used to evaluate associations with BC risk and its clinicopathological parameters. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression.

RESULTS

Strong significant association with breast cancer risk was observed for the haplotype (T-C-G) of MTHFR C677T/ MTHFR A1289C and MTRA2576G and hormonal receptor expression (ER-/PR-/HER2+), bigger and advanced tumor and metastatic lymph nodes. However, no significant difference was observed for age.

CONCLUSION

The combination of SNPs from MTHFR and MTR genes has a more synergistically genetic effect on BC disease progression. These SNPs could be used as tumor aggressiveness markers among Egyptian females with BC and could help in saving money and time.

摘要

背景

乳腺癌（BC）是仅次于肺癌的第二大致癌死亡原因，由于遗传和环境因素在世界各地存在差异。在本研究中，我们评估了编码叶酸代谢酶的基因多态性：亚甲基四氢叶酸还原酶（MTHFR）、甲硫氨酸合成还原酶（MTR）与BC预后因素之间的相互作用。

方法

本研究对160名埃及受试者进行，其中60名对照和100名病例。除了包括卡方检验、单倍型分析在内的统计分析外，还采用测序、RFLP分析来评估与BC风险及其临床病理参数的关联。使用无条件逻辑回归计算比值比（OR）和95%置信区间（CI）。

结果

观察到MTHFR C677T/MTHFR A1289C和MTR A2576G的单倍型（T-C-G）与乳腺癌风险、激素受体表达（ER-/PR-/HER2+）、更大且进展期肿瘤以及转移性淋巴结之间存在强显著关联。然而，年龄方面未观察到显著差异。

结论

MTHFR和MTR基因的单核苷酸多态性组合对BC疾病进展具有更强的协同遗传效应。这些单核苷酸多态性可作为埃及BC女性肿瘤侵袭性的标志物，有助于节省金钱和时间。