Nourolahzadeh Zahra, Houshmand Massoud, Mohammad Fawzia Mostafa, Ghorbian Saeed
Department of Molecular Biology, Ahar Branch Islamic Azad University, Ahar, Iran.
Knowledge University, Erbil Kurdistan region, Iraq.
Rep Biochem Mol Biol. 2020 Oct;9(3):291-296. doi: 10.29252/rbmb.9.3.291.
Breast cancer is classified as one of the common cancers among women worldwide. Within numerous genetic factors involved in the development of breast cancer, and genes are both located on breast cancer susceptibility locus. While the SNP in gene has a twilight association with breast cancer in different populations, polymorphisms have been reported to associate with breast tumor appearance in Asian, European, and African ancestry populations. The present report was designed a case-control group aimed at assessing the association of these two SNPs with breast cancer risk in the Iranian population.
In the case-control study of and polymorphisms in 100 women with breast cancer and 100 healthy women were examined by Tetra Arms PCR. Data collected using SPSS software and chi-square test and correlation coefficient were used for statistical analysis.
The results of current study showed that the Chi-square of and polymorphism genotypes in breast cancer, were reported to be 51.613 and 47.920, respectively. Also there has been a significance level of both polymorphisms resulting in the frequency of genotypes in these two polymorphisms between case and control group.
Our finding thus suggested that in both polymorphisms, homozygote genotype showed strong correlation with cancer susceptibility. While, TT genotype in showed significant association with pathogenic properties, in the case of genotypes CC, and in second place, TT showed similar correlation.
乳腺癌被列为全球女性常见癌症之一。在众多参与乳腺癌发生发展的遗传因素中，[基因名称1]和[基因名称2]基因均位于乳腺癌易感位点。虽然[基因名称1]基因中的单核苷酸多态性（SNP）在不同人群中与乳腺癌存在微弱关联，但[基因名称2]基因的多态性已被报道在亚洲、欧洲和非洲血统人群中与乳腺肿瘤外观有关。本报告设计了一个病例对照研究组，旨在评估这两个单核苷酸多态性与伊朗人群乳腺癌风险的关联。
在一项病例对照研究中，通过四臂PCR检测了100名乳腺癌女性和100名健康女性中[基因名称1]和[基因名称2]基因的多态性。使用SPSS软件收集数据，并采用卡方检验和相关系数进行统计分析。
当前研究结果显示，乳腺癌中[基因名称1]和[基因名称2]基因多态性基因型的卡方值分别为51.613和47.920。此外，这两种多态性均具有显著水平，导致病例组和对照组之间这两种多态性基因型的频率存在差异。
我们的研究结果表明，在这两种多态性中，纯合子基因型与癌症易感性显示出强烈相关性。虽然[基因名称1]基因的TT基因型与致病特性显示出显著关联，但在[基因名称2]基因中，CC基因型次之，TT基因型显示出类似的相关性。
