未变性II型胶原蛋白用于治疗膝关节骨关节炎。
UNDENATURED COLLAGEN TYPE II FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE.
作者信息
Sadigursky David, Magnavita Victor Filardi Stolze, Sá Cloud Kennedy Couto DE, Monteiro Henrique DE Sousa, Braghiroli Oddone Freitas Melro, Matos Marcos Antônio Almeida
机构信息
Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil.
Centro Universitário UniFTC, Salvador, BA, Brazil.
出版信息
Acta Ortop Bras. 2022 Apr 15;30(2):e240572. doi: 10.1590/1413-785220223002240572. eCollection 2022.
OBJECTIVE
To test the hypothesis that undenatured type II collagen (UC-II) relieves pain, quality of life, and joint function in women aged from 60 to 80 years with knee osteoarthritis.
METHODS
53 patients in the UC-II treatment group (for 90 days) and 52 in the control group (without UC-II) were evaluated at 1, 30, and 90 days regarding health-related quality of life, pain, and function with questionnaires, anthropometric data, alignment, range of motion, and radiographic analysis.
RESULTS
Quality of life increased significantly in the Physical domain in the treatment control group. Also, there was a difference between the first and the last evaluation on the pain visual analog scale (-3.8 ± 1.8 versus -1.3 ± 2.0) and on the WOMAC score (-9.5 ± 11.9 versus -1.3 ± 11.1). No variation in the temporal evolution of the Mental domain was found.
CONCLUSION
Pain, joint stiffness, and quality of life (Physical domain) improved with the inclusion of UC-II for 90 days to the therapeutic toolbox for knee osteoarthritis in individuals aged 60 to 80 years.
目的
检验以下假设：未变性II型胶原蛋白（UC-II）可缓解60至80岁膝骨关节炎女性的疼痛、改善生活质量和关节功能。
方法
对53例接受UC-II治疗组（为期90天）和52例对照组（未使用UC-II）的患者，在第1天、第30天和第90天进行评估，通过问卷调查、人体测量数据、对线情况、活动范围和影像学分析来了解其与健康相关的生活质量、疼痛和功能。
结果
治疗组与对照组相比，身体领域的生活质量显著提高。此外，疼痛视觉模拟量表的首次和末次评估之间存在差异（-3.8±1.8对-1.3±2.0），WOMAC评分也有差异（-9.5±11.9对-1.3±11.1）。未发现心理领域的时间演变有变化。
结论
对于60至80岁的膝骨关节炎患者，在治疗手段中加入90天的UC-II可改善疼痛、关节僵硬和生活质量（身体领域）。
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