巨噬细胞糖脂作为迁移抑制因子（MIF）受体的潜在作用。
Possible role of macrophage glycolipids as receptors for migration inhibitory factor (MIF).
作者信息
Higgins T J, Sabatino A P, Remold H G, David J R
出版信息
J Immunol. 1978 Sep;121(3):880-6.
Guinea pig peritoneal exudate cells incubated with water soluble glycolipids obtained from macrophages show an enhanced response to migration inhibitory factor. Incorporation of these glycolipids into liposomes greatly facilitates their interaction with indicator cells. Enhancement of peritoneal exudate cell responsiveness to migration inhibitory factor was specific for glycolipids from guinea pig macrophages. Glycolipids extracted from guinea pig brain and polymorphonuclear leukocytes as well as several bovine and porcine glycolipids had no effect. Specificity of enhancement was not due merely to a preferential association of macrophage glycolipids with indicator cells. The possible role of macrophage glycolipids as receptors for MIF is discussed.
用从巨噬细胞获得的水溶性糖脂孵育豚鼠腹腔渗出细胞，可增强其对迁移抑制因子的反应。将这些糖脂掺入脂质体极大地促进了它们与指示细胞的相互作用。腹腔渗出细胞对迁移抑制因子反应性的增强对豚鼠巨噬细胞的糖脂具有特异性。从豚鼠脑和多形核白细胞中提取的糖脂以及几种牛和猪的糖脂均无作用。增强的特异性不仅仅是由于巨噬细胞糖脂与指示细胞的优先结合。本文讨论了巨噬细胞糖脂作为迁移抑制因子受体的可能作用。
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